[Early treatment of neurosyphilis is crucial].

This case report of a 36-year-old man, who had sex with men, illustrates, that early identification and diagnosis of neurosyphilis are crucial. Neurosyphilis, being a rare complication of syphilis, is associated with a high risk of severe neurological symptoms such as cranial nerve dysfunction, acute or chronic altered mental status and auditory abnormalities. Treatment with recommended antibiotic regimens can effectively cure neurosyphilis, though the risk of sequelae remains.

The ablative fractional coagulation zone influences skin fluorescence intensities of topically applied test molecules-An in vitro study with fluorescence microscopy and fluorescence confocal microscopy.

Background: Ablative fractional laser (AFL) increases uptake of topically applied skin agents. The coagulation zone (CZ) surrounding vertically ablated channels may influence uptake of drugs.

Objectives: To investigate impact of CZ thickness on skin fluorescence intensities (FI) of a hydrophilic molecule by means of fluorescence microscopy (FM) and fluorescence confocal microscopy (FCM).

The fractional laser-induced coagulation zone characterized over time by laser scanning confocal microscopy-A proof of concept study.

Background: Ablative fractional laser (AFXL) is an acknowledged technique to increase uptake of topical agents in skin. Micro thermal ablation zones (MAZs) consist of ablated vertical channels surrounded by a coagulation zone (CZ). Laser scanning confocal microscopy (LSCM) images individual MAZs at 733 nm (reflectance confocal microscopy (RCM)).

Fractional laser-assisted drug uptake: Impact of time-related topical application to achieve enhanced delivery.

Background And Objective: Ablative fractional laser (AFXL) is acknowledged to increase uptake of topically applied agents in skin. AFXL channels gradually close over time, which may impair this capability. The time frame for applying a drug after AFXL exposure remains to be established.

Dynamic Optical Coherence Tomography Capillaroscopy: A New Imaging Tool in Autoimmune Connective Tissue Disease.

Importance: Vasculopathy characterized by functional and structural abnormalities of the microcirculation plays an important role in systemic sclerosis and dermatomyositis. Although there are several advantages in using capillaroscopy, the method does not offer insight on the skin architecture, flow status, or morphology of the deeper dermal vessels. Dynamic optical coherence tomography (D-OCT) is a recently developed OCT technique that enables detection of high-speed changes in back-scattered light caused by moving cells in vessels.

Spatiotemporal closure of fractional laser-ablated channels imaged by optical coherence tomography and reflectance confocal microscopy.

Background And Objective: Optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) offer high-resolution optical imaging of the skin, which may provide benefit in the context of laser-assisted drug delivery. We aimed to characterize postoperative healing of ablative fractional laser (AFXL)-induced channels and dynamics in their spatiotemporal closure using in vivo OCT and RCM techniques.

Study Design/materials And Methods: The inner forearm of healthy subjects (n = 6) was exposed to 10,600 nm fractional CO2 laser using 5 and 25% densities, 120 μm beam diameter, 5, 15, and 25 mJ/microbeam.

In vivo Imaging of Sarcoptes scabiei Infestation Using Optical Coherence Tomography.

Background: Sarcoptes scabiei can be visualized with different imaging tools. Optical coherence tomography (OCT) may have the potential to describe the changes in skin morphology due to scabies infestation and visualize the parasite.

Methods: Five patients from the Departments of Dermatology, Augsburg, Germany, and Roskilde, Denmark, were OCT scanned (VivoSight(®); Michelson Diagnostics Ltd.