Publications by authors named "Christin Riedinger"
Background: Diabetes mellitus is a significant comorbidity of interstitial lung disease (ILD).
Objectives: The aim of this study was to investigate the incidence of restrictive lung disease (RLD) and ILD in patients with prediabetes and type 2 diabetes (T2D).
Methods: Forty-eight nondiabetics, 68 patients with prediabetes, 29 newly diagnosed T2D, and 110 patients with long-term T2D were examined for metabolic control, diabetes-related complications, breathlessness, and lung function.
Aims: 5-Aminoimidazole-4-carboxamide riboside (AICAR) is an endogenous activator of AMPK, a central regulator of energy homeostasis. Loss and/or reduction of AMPK signaling plays an important role in the development of insulin resistance in type 2 diabetes. The loss of AMPK in diabetes could be due to a loss of AICAR.
View Article and Find Full Text PDFThe enzyme AICAR-transformylase/IMP cyclohydrolase (ATIC) catalyzes the last two steps of purine synthesis. It metabolizes 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), which is an AMP analogue, leading to activation of AMP-activated kinase (AMPK). We investigated whether the AICAR-ATIC pathway plays a role in the high glucose (HG)-mediated DNA damage response and AICAR-mediated AMPK activation, explaining the detrimental effects of glucose on neuronal damage and shortening of the lifespan.
View Article and Find Full Text PDFBackground: Glucose derived metabolism generates reactive metabolites affecting the neuronal system and lifespan in C. elegans. Here, the role of the insulin homologue ins-7 and its downstream effectors in the generation of high glucose induced neuronal damage and shortening of lifespan was studied.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated how human insulin and its analogues can protect against lifespan reduction and neuronal damage in the nematode Caenorhabditis elegans under high glucose conditions, similar to those found in diabetes.
- Results showed that insulin treatments countered the adverse effects of high glucose, reducing reactive oxygen species (ROS) and advanced glycation end-products (AGEs), while enhancing the activity of protective enzymes like superoxide dismutase (SOD).
- The beneficial effects of insulin were linked to a specific signaling pathway involving the daf-2 insulin receptor and the daf-16/FOXO transcription factor, which helps regulate detoxifying processes in the cells.