Assessment of canonical diurnal variations in plasma glucose using quantile regression modelling and Chronomaps.

Objectives: Diurnal variation of plasma glucose levels may contribute to diagnostic uncertainty. The permissible time interval, (), was proposed as a time-dependent characteristic to specify the time within which glucose levels from two consecutive samples are not biased by the time of blood collection. A major obstacle is the lack of population-specific data that reflect the diurnal course of a measurand.

Time-dependent characteristics of analytical measurands.

Objectives: Biological variation is a relevant component of diagnostic uncertainty. In addition to within-subject and between-subject variation, preanalytical variation also includes components that contribute to biological variability. Among these, daily recurring, i.