Association between pregnancy-related changes in serum creatinine and preeclampsia diagnosis.

Background: Preeclampsia is a leading cause of maternal and neonatal morbidity and mortality, affecting 2-8% of all pregnancies. Typically, the increased glomerular filtration rate of pregnancy results in a decrease in serum creatinine. It is unknown if women without the expected decrease in serum creatinine during pregnancy are more likely to be diagnosed with preeclampsia.

Clinical manifestations and treatment of drug-induced hepatotoxicity.

With an increase of prescription medication and herbal supplement use, drug-induced liver injury (DILI) has become an increasingly important entity. Because DILI is a usually readily treatable condition, it is essential for providers to reach a diagnosis in a timely fashion. Unfortunately, varied clinical presentations, difficulties in establishing causality, and lack of a gold standard diagnostic criterion may make early diagnosis difficult.