Publications by authors named "Christin Hesse"
Article Synopsis
- Tegaserod is a selective agonist of serotonin receptors and is primarily used to treat bowel diseases, which led researchers to investigate its effects on human cardiac atrial 5-HT receptors.
- In mice with cardiac-specific overexpression of these receptors, tegaserod demonstrated positive effects on heart muscle contraction and rate, while showing no such effects in normal mice.
- The study revealed that tegaserod enhances contraction strength in human atrial tissue, particularly when combined with cilostamide, though it acts as a partial agonist compared to serotonin and isoprenaline.
Zacopride stimulates 5-HT serotonin receptors in the human atrium.
Naunyn Schmiedebergs Arch Pharmacol
September 2024
Article Synopsis
- - Zacopride is a strong agonist for human 5-HT serotonin receptors and has potential uses as an antiemetic drug for gastric diseases and as an antiarrhythmic agent by inhibiting cardiac potassium channels.
- - In studies, zacopride increased the force of contraction and beating rate in isolated mouse atrial preparations that overexpress human 5-HT receptors but had no effect on normal mouse hearts.
- - The positive effects of zacopride on human atrial preparations were inhibited by specific serotonin receptor antagonists, indicating it acts as an agonist at these receptors in the human heart.
Mosapride stimulates human 5-HT-serotonin receptors in the heart.
Naunyn Schmiedebergs Arch Pharmacol
September 2024
Mosapride (4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl) methyl]-2-morpholinyl]-methyl] benzamide) is a potent agonist at gastrointestinal 5-HT receptors. Mosapride is an approved drug to treat several gastric diseases. We tested the hypothesis that mosapride also stimulates 5-HT receptors in the heart.
View Article and Find Full Text PDFInitial characterization of a transgenic mouse with overexpression of the human D-dopamine receptor in the heart.
Naunyn Schmiedebergs Arch Pharmacol
July 2024
Dopamine can exert effects in the mammalian heart via five different dopamine receptors. There is controversy whether dopamine receptors increase contractility in the human heart. Therefore, we have generated mice that overexpress the human D-dopamine receptor in the heart (D-TG) and hypothesized that dopamine increases force of contraction and beating rate compared to wild-type mice (WT).
View Article and Find Full Text PDFTrapping small mammals is frequently used to study the dynamics, demography, behavior and presence of pathogens. When only particular small mammal species are in the focus of interest, all other species are unnecessary bycatch. We analyzed data from extensive live trapping campaigns conducted over the last decade in Germany, following a consistent standard trapping protocol that resulted in about 18,500 captures of small mammals.
View Article and Find Full Text PDFRodentia is the most speciose mammalian order, found across the globe, with some species occurring in close proximity to humans. Furthermore, rodents are known hosts for a variety of zoonotic pathogens. Among other animal species, rodents came into focus when the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) spread through human populations across the globe, initially as laboratory animals to study the viral pathogenesis and to test countermeasures.
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