Publications by authors named "Christin Buehler"
J Clin Invest
December 2007
Article Synopsis
- Immune responses against metastatic melanoma (MM) are often weak despite effective therapies, mainly due to dendritic cells (DCs) being unable to activate T cells properly.
- The N-RAS and B-RAF mutations in MM greatly increase the expression of CD200, a suppressor of DC function, which correlates with disease progression.
- Targeting CD200 may enhance antitumor immunity by overcoming its immunosuppressive effects, suggesting it could be a valuable therapeutic target for improving treatment outcomes in MM.
