Publications by authors named "Christie L Glau"
Article Synopsis
- The study investigates the effectiveness of enoxaparin, a medication for preventing blood clots, in critically ill children, focusing on differences in response based on age, particularly between older children and infants.
- It consists of two simultaneous clinical trials: one for older children aged 1-17 years, and another for infants under 1 year, with specific dosing protocols for each group.
- The trials are set in multiple pediatric intensive care units across the U.S., using methods like randomization, ultrasonography, and blood analysis to assess outcomes and monitor safety.
Evolution and Impact of a Diagnostic Point-of-Care Ultrasound Program in a PICU.
Pediatr Crit Care Med
November 2024
Article Synopsis
- The study aimed to assess how point-of-care ultrasound (POCUS) impacts clinicians in a pediatric intensive care unit (PICU) and to evaluate the development of the POCUS program.
- Over the study period from 2017 to 2022, nearly 7,201 POCUS studies were performed, with a significant number leading to changes in clinician understanding and management of patient care, especially in cardiac cases.
- The findings showed an increase in POCUS orders and revenue, while also highlighting the need to adapt quality assurance processes as technology and clinical practices evolve.
Article Synopsis
- - Pediatric point-of-care ultrasonography (POCUS) is increasingly important in pediatric acute care, expanding beyond initial uses like assessing shock and trauma.
- - Recent guidelines have been published to help healthcare professionals implement POCUS effectively in clinical settings.
- - The review covers new uses and debates around POCUS in areas such as thoracic, hemodynamic, neurologic, and ocular care for children.
Article Synopsis
- Ultrasound assessments of the diaphragm in healthy children under 18 were studied to establish baseline thickness and contractility values, highlighting the need for pediatric-specific data in acute care.
- Measurements included diaphragm thickness during breathing and ventilation, with outcomes compared across different age groups and conditions (spontaneous vs. mechanical ventilation).
- Results showed no significant age-related differences in diaphragm thickness and thickening fraction, but diaphragm excursion and strain improved with age; however, all contractility measures decreased significantly during mechanical ventilation.
Objectives: To assess focused cardiac ultrasound impact on clinician hemodynamic characterization of patients with suspected septic shock as well as expert-generated focused cardiac ultrasound algorithm performance.
Design: Retrospective, observational study.
Setting: Single-center, noncardiac PICU.
Healthcare regulatory bodies have escalated concerns regarding the use of point-of-care ultrasound by nonradiology and noncardiology physicians. A recently published PCCMPerspective identified that data do not support many of these concerns and addressed common misconceptions associated with point-of-care ultrasound use in the critical care setting. Indeed, the global point-of-care ultrasound community and specifically the pediatric critical care community have the opportunity to be leaders in demonstrating how to translate new skills and technologies to the bedside in a safe and effective manner.
View Article and Find Full Text PDFObjectives: Diaphragm atrophy is evident during invasive ventilation for pediatric acute respiratory failure, but with unknown significance. We hypothesized that diaphragm atrophy in pediatric acute respiratory failure is associated with prolonged noninvasive positive pressure ventilation following extubation.
Design: Prospective observational study.
Point-of-care ultrasound is currently widely used across the landscape of pediatric care. Ultrasound machines are now smaller, are easier to use, and have much improved image quality. They have become common in emergency departments, ICUs, inpatient wards, and outpatient clinics.
View Article and Find Full Text PDFHigh-frequency oscillatory ventilation (HFOV) is a mode of mechanical ventilation used in severe pediatric respiratory failure. Thoracic ultrasound (US) is a powerful tool for diagnosing acute pathophysiologic conditions during spontaneous respiration and conventional noninvasive and invasive mechanical ventilation. High-frequency oscillatory ventilation differs from conventional modes of ventilation in that it does not primarily use bulk flow delivery for gas exchange but, rather, a number of alternative mechanisms as the result of pressure variations oscillating around a constant distending pressure.
View Article and Find Full Text PDFProgressive Diaphragm Atrophy in Pediatric Acute Respiratory Failure.
Pediatr Crit Care Med
May 2018
Objectives: Diaphragm atrophy is associated with delayed weaning from mechanical ventilation and increased mortality in critically ill adults. We sought to test for the presence of diaphragm atrophy in children with acute respiratory failure.
Design: Prospective, observational study.