Human Monocyte-Derived Macrophages Demonstrate Distinct Responses to Ambient Particulate Matter in a Polarization State- and Particle Seasonality-Specific Manner.

Macrophages are professional phagocytic immune cells that, following activation, polarize on a spectrum between the proinflammatory M1 and the proresolution M2 states. Macrophages have further been demonstrated to retain plasticity, allowing for the reprogramming of their polarization states following exposure to new stimuli. Particulate matter (PM) has been repeatedly shown to modify macrophage function and polarization while also inducing worsening respiratory infection morbidity and mortality.

PedsTalk: A Pilot Communication Skills Education Course for Pediatric Residents.

Objective: Communication skills are critical to pediatric practice, but few pediatric residency programs provide formal communication skills education. Pediatric residents often lack confidence in these skills. We hypothesized that a simulation-based communication skills course would improve resident confidence in the skills required for serious illness conversations with patients/families.

Variability in low-flow oxygen delivery by nasal cannula evaluated in neonatal and infant airway replicas.

Background: The nasal cannula is considered a trusted and effective means of administering low-flow oxygen and is widely used for neonates and infants requiring oxygen therapy, despite an understanding that oxygen concentrations delivered to patients are variable.

Methods: In the present study, realistic nasal airway replicas derived from medical scans of children less than 3 months old were used to measure the fraction of oxygen inhaled (FiO) through nasal cannulas during low-flow oxygen delivery. Parameters influencing variability in FiO were evaluated, as was the hypothesis that measured FiO values could be predicted using a simple, flow-weighted calculation that assumes ideal mixing of oxygen with entrained room air.

Cephalopod-inspired robot capable of cyclic jet propulsion through shape change.

The compliance and conformability of soft robots provide inherent advantages when working around delicate objects or in unstructured environments. However, rapid locomotion in soft robotics is challenging due to the slow propagation of motion in compliant structures, particularly underwater. Cephalopods overcome this challenge using jet propulsion and the added mass effect to achieve rapid, efficient propulsion underwater without a skeleton.

cake for broiler chickens: effects of increasing dietary inclusion on clinical signs of toxicity, feed disappearance, and nutrient digestibility.

The effect of feeding diets with increasing dietary inclusions of cake (CC; 22% ether extract, 34% crude protein) on safety, feed disappearance, and nutrient digestibility was evaluated in a 42-day (d) broiler study. Day-old male chicks (Ross 308; = 744) were divided among 24 test cages in a randomized complete block design with six replicate cages per dietary regimen. Dietary regimens consisted of feeding test diets containing 0, 8, 16, or 24% CC over three growth phases of 2-week duration each.

Jellyfish-Inspired Soft Robot Driven by Fluid Electrode Dielectric Organic Robotic Actuators.

Robots for underwater exploration are typically comprised of rigid materials and driven by propellers or jet thrusters, which consume a significant amount of power. Large power consumption necessitates a sizeable battery, which limits the ability to design a small robot. Propellers and jet thrusters generate considerable noise and vibration, which is counterproductive when studying acoustic signals or studying timid species.

Design Considerations for 3D Printed, Soft, Multimaterial Resistive Sensors for Soft Robotics.

Sensor design for soft robots is a challenging problem because of the wide range of design parameters (e.g., geometry, material, actuation type, etc.

Simultaneous extraction and analysis of multiple cystine-dense peptides by μSPE and microflow-MS/MS from plasma.

Develop a universal extraction and liquid chromatography-mass spectrometer method to simultaneously analyze cystine-dense peptide (CDP) miniproteins from rat and human plasma. The results of the analysis will be used to assist selection of therapeutic drug candidates from the vast CDP library. A micro-elution solid-phase extraction method was developed for the sample preparation of the CDP peptides in rat and human plasma followed by analysis by microflow liquid chromatography MS/MS.

Translucent soft robots driven by frameless fluid electrode dielectric elastomer actuators.

Dielectric elastomer actuators (DEAs) are a promising enabling technology for a wide range of emerging applications, including robotics, artificial muscles, and microfluidics. This is due to their large actuation strains, rapid response rate, low cost and low noise, high energy density, and high efficiency when compared with alternative actuators. These properties make DEAs ideal for the actuation of soft submersible devices, although their use has been limited because of three main challenges: (i) developing suitable, compliant electrode materials; (ii) the need to effectively insulate the actuator electrodes from the surrounding fluid; and (iii) the rigid frames typically required to prestrain the dielectric layers.

Do Gold Humanism Honor Society Inductees Differ From Their Peers in Empathy, Patient-Centeredness, Tolerance of Ambiguity, Coping Style, and Perception of the Learning Environment?

Unlabelled: Construct: Induction into the Gold Humanism Honor Society (GHHS) during medical school is recognized as an indicator of humanistic orientation and behavior. Various attitudes and interpersonal orientations including empathy and patient-centeredness have been posited to translate into behaviors constituting humanistic care.

Background: To our knowledge there has never been a longitudinal, multi-institutional empirical study of the attitudinal and interpersonal orientations correlated with GHHS membership status.

A Biologically Inspired, Functionally Graded End Effector for Soft Robotics Applications.

Soft robotic actuators offer many advantages over their rigid counterparts, but they often are unable to apply highly localized point loads. In contrast, many invertebrates have not only evolved extremely strong "hybrid appendages" that are composed of rigid ends that can grasp, puncture, and anchor into solid substrates, but they also are compliant and resilient, owing to the functionally graded architecture that integrates rigid termini with their flexible and highly extensible soft musculatures. Inspired by the design principles of these natural hybrid appendages, we demonstrate a synthetic hybrid end effector for soft-bodied robots that exhibits excellent piercing abilities.

Medical Student Perceptions of the Learning Environment at the End of the First Year: A 28-Medical School Collaborative.

Purpose: Accreditation and professional organizations have recognized the importance of measuring medical students' perceptions of the learning environment, which influences well-being and professional competency development, to optimize professional development. This study was conducted to explore interactions between students' perceptions of the medical school learning environment, student demographic variables, and students' professional attributes of empathy, coping, tolerance of ambiguity, and patient-centeredness to provide ideas for improving the learning environment.

Method: Twenty-eight medical schools at 38 campuses recruited 4,664 entering medical students to participate in the two-cohort longitudinal study (2010-2014 or 2011-2015).

Vapor-Driven Propulsion of Catalytic Micromotors.

Chemically-powered micromotors offer exciting opportunities in diverse fields, including therapeutic delivery, environmental remediation, and nanoscale manufacturing. However, these nanovehicles require direct addition of high concentration of chemical fuel to the motor solution for their propulsion. We report the efficient vapor-powered propulsion of catalytic micromotors without direct addition of fuel to the micromotor solution.

RBC micromotors carrying multiple cargos towards potential theranostic applications.

Red blood cell (RBC)-based micromotors containing both therapeutic and diagnostic modalities are described as a means for potential theranostic applications. In this natural RBC-based multicargo-loaded micromotor system, quantum dots (QDs), anti-cancer drug doxorubicin (DOX), and magnetic nanoparticles (MNPs), were co-encapsulated into RBC micromotors. The fluorescent emission of both QDs and DOX provides direct visualization of their loading inside the RBC motors at two distinct wavelengths.

Persistence of asthma requires multiple feedback circuits involving type 2 innate lymphoid cells and IL-33.

Background: Asthma in a mouse model spontaneously resolves after cessation of allergen exposure. We developed a mouse model in which asthma features persisted for 6 months after cessation of allergen exposure.

Objective: We sought to elucidate factors contributing to the persistence of asthma.

Turning erythrocytes into functional micromotors.

Attempts to apply artificial nano/micromotors for diverse biomedical applications have inspired a variety of strategies for designing motors with diverse propulsion mechanisms and functions. However, existing artificial motors are made exclusively of synthetic materials, which are subject to serious immune attack and clearance upon entering the bloodstream. Herein we report an elegant approach that turns natural red blood cells (RBCs) into functional micromotors with the aid of ultrasound propulsion and magnetic guidance.

Dimension effect on the performance of carbon nanotube nanobolometers.

Carbon nanotube (CNT) film nanobolometers take advantages of high infrared absorption of CNTs, proving a promising alternative for low-cost, uncooled infrared detection. The performance of the CNT nanobolometers is determined by the optoelectronic process on CNTs at a microscopic scale, which links intimately to the diameter of the CNT-a critical parameter that intrinsically affects the band gap and hence infrared absorption, as well as extrinsically affects the surface oxygen adsorption effect and thermal-link of the CNT detector element to the environment. Both the intrinsic and extrinsic factors play important roles in the photoresponse, noise spectrum and the figure-of-merit detectivity D* of the CNT nanobolometers and their interplay determines the device's ultimate performance.

Use of a patient-entered family health history tool with decision support in primary care: impact of identification of increased risk patients on genetic counseling attendance.

Several barriers inhibit collection and use of detailed family health history (FHH) in primary care. MeTree, a computer-based FHH intake and risk assessment tool with clinical decision support, was developed to overcome these barriers. Here, we describe the impact of MeTree on genetic counseling (GC) referrals and attendance.

Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma.

Background: TH2 cells can further differentiate into dual-positive TH2/TH17 cells. The presence of dual-positive TH2/TH17 cells in the airways and their effect on asthma severity are unknown.

Objective: We sought to study dual-positive TH2/TH17 cells in bronchoalveolar lavage (BAL) fluid from asthmatic patients, examine their response to glucocorticoids, and define their relevance for disease severity.

First Report of Bacterial Blight of Carrot in Indiana Caused by Xanthomonas hortorum pv. carotae.

In summer 2012, bacterial blight symptoms (2) were observed on leaves of carrot plants in 7 out of 70 plots of carrot breeding lines at the Purdue University Meig Horticulture Research Farm, Lafayette, IN. Symptoms included small to large, variably shaped, water-soaked to dry, necrotic lesions, with or without chlorosis, at <5% incidence. Microscopic examination of symptomatic leaf sections revealed bacterial streaming from the cut ends of each leaf piece.

High photoresponse in hybrid graphene-carbon nanotube infrared detectors.

Efficient exciton dissociation is crucial to obtaining high photonic response in photodetectors. This work explores implementation of a novel exciton dissociation mechanism through heterojunctions self-assembled at the graphene/MWCNT (multiwall carbon nanotube) interfaces in graphene/MWCNT nanohybrids. Significantly enhanced near-infrared photoresponsivity by nearly an order of magnitude has been achieved on the graphene/MWCNT nanohybrids as compared to the best achieved so far on carbon nanotube (CNT) only infrared (IR) detectors.