Reversible colour vision defects in obstructive jaundice.

The ocular function of 14 non-alcoholic, high icteric patients with recent occlusion of the common bile duct and 3 patients with viral hepatitis with a cholestatic pattern was studied. By means of a colour vision test panel including the Farnsworth-Munsell 100-hue test, 12 patients were initially classified as colour defective with a pattern of acquired colour vision deficiency (ACVD), predominantly of a tritan type. Visual acuity, visual field, slit lamp microscopy, intraocular pressure, ophthalmoscopy and tear secretion tests were normal, and all patients had normal levels of serum vitamin A.

Hypotension during and after operation in glucocorticoid-treated patients.

The frequency and likely aetiology of systemic arterial hypotension occurring either during or following operation, in patients receiving steroids was analysed retrospectively. Hypotension occurred during surgery in 29 of 250 operations. Although patients receiving steroids until shortly before operation appeared more likely to develop hypotension during operation the differences were eliminated when allowance was made for the severity of the disease.

Cloning, restriction endonuclease mapping and post-transcriptional regulation of rpsA, the structural gene for ribosomal protein S1.

Transducing lambda phages have been isolated that carry segments of the Escherichia coli chromosome in the aspC region, 20.5 min on the E. coli map.

A fully active, two-active-site, single-chain sucrase.isomaltase from pig small intestine. Implications for the biosynthesis of a mammalian integral stalked membrane protein.

Detergent-solubilized pig intestinal sucrase . isomaltase (EC 3.2.

Possible antagonists to gastrin in parathyroid adenomas.

The high incidence of gastroduodenal ulcers in patients with hyperparathyroidism has been ascribed to gastric hyperacidity induced by hypercalcaemia. In a clinical study comprising 40 patients with solitary parathyroid adenoma, a negative correlation between serum calcium and spontaneous gastric acid secretion was found. At the same time a positive correlation was found between serum calcium and gastrin.

The antral gastrin-producing cells in duodenal ulcer patients. A density study before and during treatment with cimetidine.

A density study of the antral gastrin-producing cells has been performed, before and after eight weeks of treatment with a histamine H2-receptor antagonist (cimetidine 1 g per day), in a series of 38 patients suffering from chronic duodenal ulcer. The treatment produced a significant increase in numerical density and a decrease in mean cell volume. The volume density of the cells was unchanged, suggesting that the elevated serum-gastrin during treatment may be the result of gastrin-cell hyperplasia, without change in the total gastrin-cell volume.

Antibotulinal efficacy of sulfur dioxide in meat.

The addition of sodium metabisulfite as a source of sulfur dioxide delayed botulinal outgrowth in perishable canned comminuted pork when it was temperature abused at 27 degree C. The degree of inhibition was directly related to the level of sulfur dioxide. Levels greater than 100 microgram of sulfur dioxide per g were necessary to achieve significant inhibition when a target level of 100 botulinal spores per g was used.

Gastric release in pigs during intestinal pouch stimulation with meat extract.

In six pigs the gastric concentrations in the pancreaticoduodenal vein were slightly, but significantly, higher than in the carotid artery (p < 0.05). After instillation of meat extract into the duodenal pouches the gastrin concentrations in the pancreaticoduodenal vein increased significantly (p < 0.

The parietal cells in duodenal ulcer patients. A quantitative ultrastructural study before and during treatment with cimetidine.

Quantitative ultrastructural analyses of the parietal cells have been performed on eleven patients with chronic duodenal ulcer, before and after 8 weeks' treatment with a histamine H2-receptor antagonist (cimetidine, 1 g/day). The treatment caused a significant decrease of the secretory surface density; this result seems to differ from those of ultrastructural reports on parietal cells when acid secretion is inhibited by vagotomy. Furthermore, it was demonstrated that the profile of the tubulo-vesicles of parietal cells could be seen in three phases, tentatively suggesting that this system is able to take up material from the surrounding cytoplasm by encircling it.

Iron and the antibotulinal efficacy of nitrite.

Combination of nitrite, isoascorbate, and ethylenediaminetetraacetic acid were compared for their antibotulinal efficacy in perishable canned cured meat. A dose response relationship of available iron to the antibotulinal efficacy of nitrite was demonstrated.

Serum disappearance rate of gastrin-17 after vagotomy.

Six duodenal ulcer patients were investigated before and after truncal vagotomy and pyloroplasty. Four doses of gastrin-17 were injected intravenously (15.625, 31.

Renal and cerebral blood flow in experimental liver failure in the pig.

The renal and cerebral blood flow was measured in six pigs after total devascularization of the liver. The animals died 21 to 26 h after the operation, with biochemical and electroencephalographic changes compatible with liver failure. The renal blood flow increased slightly, from 2.

Delay in the diagnosis of insulinomas.

The median diagnostic delay in 32 patients with verified insulinomas was 2 3/4 years (range 1/4--18). The median delay in the 1939--1958 period was shorter (2 years, n = 17) than in the 1959--1978 period (3 years, n = 15). Thus, modern developments with insulin estimations were without noticeable effect upon the diagnostic delay.

Effect of Potassium Sorbate on Toxinogenesis by Clostridium botulinum in Bacon.

In an effort to reduce the initial levels of nitrite used to cure bacon and still supply the botulinal inhibition expected in cured meats, bacon was produced at nitrite levels of 0 and 40 ppm NaNO with and without 0.13 and 0.26% potassium sorbate.

Non-operative treatment of retained bile duct calculi in patients with an indwelling T tube.

The results of combined instrumental and chemical treatment of retained bile duct calculi in 18 patients with an indwelling T tube are reported. The instrumental extraction of stones was carried out through the T tube channel using a modified Dormia apparatus. The chemical method involved continuous infusion through the T tube of heparin in saline alternating with sodium cholate.

Fate of Clostridium botulinum in Perishable Canned Cured Meat at Abuse Temperature.

Three experiments are described wherein perishable canned cured pork was prepared with 50 or 156 μg/g added sodium nitrite and 10 or 10 botulinal spores/g. Spore germination (i.e.

Causes of variation in botulinal inhibition in perishable canned cured meat.

Final internal processing temperatures within the range of 63 to 74 degrees C did not alter the degree of botulinal inhibition in inoculated perishable canned comminuted cured pork abused at 27 degrees C. Adding hemoglobin to the formulation reduced residual nitrite after processing and decreased botulinal inhibition. Different meats yielded different rates of botulinal outgrowth when substituted for fresh pork ham.

Effect of prior refrigeration on botulinal outgrowth in perishable canned cured meat when temperature abused.

Perishable canned cured meat inoculated with Clostridium botulinum spores was placed at 4.4 or 10 degrees C after manufacture. Spore germination occurred at 10 degrees C.