Genetic polymorphisms underlying the skeletal Class III phenotype.

Introduction: Our goal was to verify the association between candidate polymorphisms and skeletal Class III malocclusion in a well-characterized homogeneous sample set.

Methods: Thirty-five single-nucleotide polymorphisms were studied from 10 candidate loci in 54 Class III subjects and 120 controls. Skeletal Class III characteristics included ANB angle less than 0°, SNB angle greater than 83° (mandibular prognathism), SNA angle less than 79° (maxillary deficiency), Class III molar relationship, and negative overjet.

Reliability of upper airway linear, area, and volumetric measurements in cone-beam computed tomography.

Introduction: Our objective was to assess the intraexaminer and interexaminer reliabilities of upper airway linear, area, and volumetric measurements in cone-beam computed tomography.

Methods: Cone-beam computed tomography scans of 12 subjects were randomly selected from a pool of 132 orthodontic patients. An undergraduate student, an orthodontist, and a dental radiologist independently made linear, area, and volumetric measurements.