Publications by authors named "Christiane Kotthoff"
Article Synopsis
- Vertebrate genomes have three large histone H2A variants, including macroH2A, which influence chromatin structure and gene regulation.
- A study developed a split-GFP assay to investigate how macroH2A is integrated into chromatin and identified ANP32B as a key protein that aids in its deposition.
- ANP32B not only associates with macroH2A but also promotes its incorporation into nucleosomes, suggesting it plays a crucial role in regulating macroH2A dynamics in cells.
DNA damage triggers chromatin remodeling by mechanisms that are poorly understood. The oncogene and chromatin remodeler ALC1/CHD1L massively decompacts chromatin in vivo yet is inactive prior to DNA-damage-mediated PARP1 induction. We show that the interaction of the ALC1 macrodomain with the ATPase module mediates auto-inhibition.
View Article and Find Full Text PDFFacilitates chromatin transcription (FACT) is a conserved histone chaperone that reorganizes nucleosomes and ensures chromatin integrity during DNA transcription, replication and repair. Key to the broad functions of FACT is its recognition of histones H2A-H2B (ref. 2).
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