Publications by authors named "Christiane Gerhards"
Working memory (WM), a key component of cognitive functions, is often impaired in psychiatric disorders such as schizophrenia. Through a genome-guided drug repurposing approach, we identified fampridine, a potassium channel blocker used to improve walking in multiple sclerosis, as a candidate for modulating WM. In a subsequent double-blind, randomized, placebo-controlled, crossover trial in 43 healthy young adults (ClinicalTrials.
View Article and Find Full Text PDFBackground: To assess the psychological consequences of changes during the coronavirus 2019 (COVID-19) pandemic in the Iranian population.
Methods: We performed an anonymous online survey in the first 3 weeks of March 2020. Individuals older than 14 who could read Persian, and lived in Iran, were eligible for the study.
Article Synopsis
- The study looked at how looking at emotional pictures affects the brain later on, especially how different brain areas connect with each other.
- Researchers used an MRI scan to see if showing scary or sad pictures changes the way the brain works compared to neutral pictures in 34 healthy young adults.
- They found that even though the scary pictures made people feel strong emotions, it didn’t change how different parts of the brain were connected when people were resting afterwards.
Human genome-guided identification of memory-modulating drugs.
Proc Natl Acad Sci U S A
November 2013
In the last decade there has been an exponential increase in knowledge about the genetic basis of complex human traits, including neuropsychiatric disorders. It is not clear, however, to what extent this knowledge can be used as a starting point for drug identification, one of the central hopes of the human genome project. The aim of the present study was to identify memory-modulating compounds through the use of human genetic information.
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