The relevance of tumor target expression levels on IgA-mediated cytotoxicity in cancer immunotherapy.

Recent advances in cancer immunotherapy, particularly the success of immune checkpoint inhibitors, have reignited interest in targeted monoclonal antibodies for immunotherapy. Antibody therapies aim to minimize on-target, off-tumor toxicity by targeting antigens overexpressed on tumor cells but not on healthy cells. Despite considerable efforts, some therapeutic antibodies have been linked to dose-limiting side effects.

Health insurance subsidies and deductible choice: Evidence from regional variation in subsidy schemes.

The extent to which premium subsidies can influence health insurance choices is an open question. In this paper, we explore the regional variation in subsidy schemes in Switzerland, designed as either in-kind or cash transfers, to study their impact on the choice of health insurance deductibles. Using health survey data and a difference-in-differences methodology, we find that in-kind transfers increase the likelihood of choosing a low deductible plan by approximately 4 percentage points (or 7%).

The adverse impact of obesity on heart rate variability is modified by a NFE2L2 gene variant: The SAPALDIA cohort.

Background: Overweight has been associated with an increase in inflammatory markers and with an imbalance in the autonomic nervous system, such as a decrease in heart rate variability (HRV). In this study we aimed to investigate the modifying effect of a genetic variation in a major anti-inflammatory marker gene, NFE2L2, on the relationship between overweight and HRV.

Methods: We analyzed participants of the SAPALDIA cohort aged 50years and older, twice in 2002/2003 (N=1472) and 2010/2011 (N=1235).

MCMI-III as a treatment outcome measure for psychiatric inpatients.

The Million Clinical Multiaxial Inventory-III (MCMI-III) recently was introduced to replace and update the MCMI-II. A sample of 97 psychiatric inpatients were administered the MCMI-III shortly following admission, and again 7-10 days later. Changes in the personality and symptom scales generally paralleled those found in previous work with the MCMI-II, although the mean retest interval was considerably shorter than in the earlier study.

Comparison of psychiatric day hospital patient and inpatient scores on the MCMI-III.

This study contrasts self-reported symptomatology on the MCMI-III of a sample of 97 psychiatric patients admitted directly to inpatient care with a sample of 75 patients admitted directly to day hospital treatment. The predominant Axis I diagnosis of patients in both samples was an affective disorder. Effect sizes of the degree of change from admission to retesting one week later were calculated and fell generally within the medium effect size range.

The relationship of length of stay to MCMI-II and MCMI-III change scores.

Differences between short versus longer lengths of stay on inpatient change scores were evaluated. Test-retest scores of 98 adult psychiatric inpatients tested with the MCMI-II in 1989 were compared with test-retest scores of 97 adult inpatients tested with the MCMI-III in 1995. The two samples of patients were comparable on demographic and diagnostic variables.

The GAF and psychiatric outcome: a descriptive report.

Since the Global Assessment of Functioning Scale (GAF) was introduced in DSM-III-R in 1987, it has been widely used, but minimally researched. This report provides information concerning the use of the GAF in routine clinical practice. Clinicians rated adult inpatients, adult day hospital patients, and adolescent inpatients at admission and discharge from psychiatric treatment.

Agreement between patient self-report and clinician rating: concurrence between the BSI and the GAF among psychiatric inpatients.

Two rating scales were compared for 200 adult psychiatric inpatients at admission to, and discharge from, the hospital. Patients rated their own psychological symptoms on the Brief Symptom Inventory (BSI), and clinicians rated patients' psychological, social, and occupational functioning on the Global Assessment of Functioning (GAF) Scale. Analyses indicated no significant relationships between symptom distress reported by patients and global functioning rated by clinicians.

Unidimensionality of the Brief Symptom Inventory (BSI) in adult and adolescent inpatients.

This study investigated the factor structure of the Brief Symptom Inventory (BSI; Derogatis, 1992) for adult and adolescent psychiatric inpatients. The BSI was administered to 217 adults and 188 adolescents at admission and discharge from a private psychiatric hospital. Principal components factor analyses revealed that most variance among dimension scores was accounted for by one unrotated factor.

The Brief Symptom Inventory (BSI) as an outcome measure for adult psychiatric inpatients.

In this study the Brief Symptom Inventory (BSI; Derogatis & Spencer, 1982) was administered to 89 males and 128 females at admission and discharge from a private psychiatric hospital. For mean scores, statistically significant decreases were observed on all BSI scales and global indices. Effect sizes ranged from high medium to large.

The Brief Symptom Inventory as an Outcome Measure for Adolescent Psychiatric Inpatients.

The utility of the Brief Symptom Inventory (BSI) as an outcome measure for adolescent psychiatric inpatients was evaluated. The BSI was administered to 88 male and 100 female psychiatric inpatients at admission and discharge. There were statistically significant mean score changes from pretest to posttest on most BSI indices, with effect sizes ranging between small and medium.

The MAPI as a treatment outcome measure for adolescent inpatients.

The Millon Adolescent Personality Inventory (MAPI; Millon, Green, & Meagher, 1982) was administered at admission and discharge to 215 hospitalized adolescents. Significant mean score differences were found for both internalizing (affective disorder) and externalizing (disruptive behavior disorder) adolescents. Consistent with theory, internalizing adolescents reported significantly greater distress at both admission and discharge than externalizing adolescents.