Publications by authors named "Christiane Aguiar Nobre"
Objective: is broadly used by folk medicine due to its anti-inflammatory effects, but there is a lack of preclinical data on its pharmacological mechanisms. This study investigated the efficacy of Chresta martii ethanolic extract (CEE) in the zymosan-induced temporomandibular joint arthritis (TMJ) and evaluated the possible role of TNF-α, nitric oxide (NO), and heme oxygenase-1 (HO-1).
Methods: Male Wistar rats (160-220 g) were pre-treated with CEE (100, 200 or 400 mg/kg; v.
It is recommended to evaluate the presence of latent tuberculosis infection (LTBI) prior to the use of antitumor necrosis factor α. The aim of this study is to assess the presence of LTBI in patients with rheumatic diseases undergoing treatment with infliximab in an endemic area for tuberculosis (TB). LTBI was searched through the contact history, chest X-ray and tuberculin skin test with purified protein derivative (PPD) ≥5 mm.
View Article and Find Full Text PDFObjective: To identify tuberculosis infection in rheumatic patients on infliximab by use of PPD testing prior to immunobiologic therapy.
Methods: This study comprised 157 patients undergoing infliximab treatment and 734 other patients undergoing laboratory screening for tuberculosis infection originating from several services. The Mantoux technique was used for PPD testing, and an induration of at least 5 mm was considered reactive status.
Amyloidosis is a heterogeneous group of diseases characterized by extracellular deposits of a material composed of aggregates of amyloid--a poorly coupled protein--far from the site of synthesis, causing target organ dysfunction and clinical disease. Systemic amyloidosis A (AA), secondary to infections and chronic inflammation, especially rheumatoid arthritis (RA), is the most common form of amyloid deposition. Treatment of AA consists in the control or resolution of the baseline condition.
View Article and Find Full Text PDFWegener's granulomatosis: prevalence of the initial clinical manifestations--report of six cases and review of the literature.
Rev Bras Reumatol
June 2011
Article Synopsis
- The study aimed to describe the initial clinical symptoms of Wegener's Granulomatosis (WG) in a Brazilian population, analyzing six medical cases and reviewing existing literature.
- The analysis found that out of 49 patients, most were female, with 73% showing systemic disease and an average onset age of about 42 years.
- It was noted that 41% had acute symptoms occurring within three months of diagnosis, while insidious symptom onset was more common, which could lead to delays in diagnosis and increased health risks.