Publications by authors named "Christiana Victoria Cismaru"
Article Synopsis
- The M2 protein of influenza A virus (IAV) plays a critical role in virus uncoating and maintaining the structure of hemagglutinin (HA), but bat IAV M2 proteins show significant differences in their amino acid sequences compared to conventional IAV, leading to potential functional variations.
- Research revealed that bat IAV M2 proteins are less effective at protecting HA from low pH changes, indicating lower proton channel activity, and specific mutations like N31S can make these proteins more sensitive to antiviral drugs like amantadine.
- The unique characteristics of bat IAV M2 proteins may help reduce their cytotoxic effects and inflammation, suggesting an evolutionary adaptation that allows these viruses to interact differently with their
