The Role of the Androgen Receptor Signaling in Breast Malignancies.

Breast cancer (BrCa) is the most common malignancy among women worldwide, and one of the leading causes of cancer-related deaths in females. Despite the development of novel therapeutic modalities, triple-negative breast cancer (TNBC) remains an incurable disease. Androgen receptor (AR) is widely expressed in BrCa and its role in the disease may differ depending on the molecular subtype and the stage.

The causative agents in infective endocarditis: a systematic review comprising 33,214 cases.

Infective endocarditis (IE) incidence remains high with considerable fatality rates; guidelines for prophylaxis against IE are currently under review in some settings which highlights the importance of maintaining up-to-date epidemiological estimates about the most common microbial causes. The objective of this systematic review, following PRISMA guidelines, was to identify the most common microbial causes of IE in recent years. Medline was searched from January 1, 2003 to March 31, 2013 for all articles containing the term "infective endocarditis".

Review: The Role of Insulin-like Growth Factor-1 Signaling Pathways in Uterine Leiomyoma.

A growing body of evidence suggests the association of the IGF-I bio-regulatory system with leiomyoma occurrence and growth. The complex interplay between IGF-I/IGF-IR and hormonal and other growth factors is, thus, now receiving significant attention. Elucidation of the molecular mechanisms driving the disease may allow for development of novel targeted-therapeutic strategies for the treatment of leiomyomas.