Severe Hemorrhage Associated With Oral Anticoagulants.

Background: Few data have been published to date on outcomes after the common clinical experience of severe hemorrhage in orally anticoagulated patients.

Methods: A prospective, multicenter observational study was carried out to investigate outcomes and management in a series of consecutive patients who sustained a severe hemorrhage under treatment with vitamin K antagonists (VKA) or direct oral anticoagulant drugs (DOAC). The primary endpoint was in-hospital death up to and including day 30 after hospital admission.

The impact of antenatal factor XIII levels on postpartum haemorrhage: a prospective observational study.

Purpose: Postpartum haemorrhage (PPH) is a leading cause of maternal mortality and morbidity. Our aim was to investigate the relationships between antenatal factor XIII (FXIII), fibrinogen levels, and blood loss at childbirth.

Methods: This prospective observational study evaluated an unselected cohort of pregnant women admitted for intended vaginal deliveries of singletons at term.