Publications by authors named "Christian Torp Pedersen"
Background: Sparse information regarding the long-term risk of acute myocardial infarction (MI) following a transient ischemic attack (TIA) emphasizes further research to guide preventive strategies and risk stratification in patients with a TIA.
Methods: We conducted a nationwide cohort study to investigate the 5-year risk of MI and all-cause mortality in patients with a first-time TIA. Patients with a first-time TIA were identified in the Danish Stroke Registry (2013-2020), matched on age, sex, and calendar year (1:4) with the general population and (1:1) with patients with first-time ischemic stroke.
Background: Chronic kidney disease (CKD) is frequently complicated by arrhythmias, plausibly leading to the increased risk of sudden cardiac death in this population. However, little is known about the association between CKD and third-degree atrioventricular block (3AVB) and need for permanent pacing.
Objectives: This study aimed to investigate the association between CKD and 3AVB.
Purpose: Bacteremia is a well-known complication to surgery and may result in infective endocarditis (IE). Transurethral resection of the prostate (TUR-P) may give rise to bacteremia, but the associated risk of IE is not well described. We aimed to examine risk of infective endocarditis following TUR-P.
View Article and Find Full Text PDFBackground: Little is known about long-term outcomes beyond survival following acute aortic dissection. The aim of this research was to evaluate rates of home care initiation and nursing home admission during the first year after discharge and to assess factors associated with these needs.
Methods: All patients in Denmark with a first-time diagnosis of acute aortic dissection type A or B between 2006 and 2015 were identified using national registries.
Aims: Although certain autoimmune diseases (AIDs) have been associated with an increased rate of heart failure (HF), data on the long-term rate of HF across the spectrum of AIDs are lacking. We investigated the long-term rate of HF in individuals with a history of 28 different AIDs.
Methods And Results: Individuals diagnosed with an AID (2000-2021) were identified through Danish nationwide registries.
It is not well investigated whether exposure to specific drug classes is associated with COVID-19. We investigated the risk of SARS-CoV-2 infection and severe COVID-19 among healthcare workers according to prescription drug use. We conducted an observational study among Danish healthcare workers.
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- The study analyzes sudden cardiac death (SCD) trends in young people (1-35 years) in Denmark from 2000 to 2019, finding a significant overall decline in SCD incidence, decreasing by 3.31% annually.
- It highlights that while witnessed SCD rates dropped significantly, unwitnessed cases remained stable, leading to a 79% increase in the proportion of unwitnessed SCDs.
- Additionally, survival rates after out-of-hospital cardiac arrest (OHCA) improved from 3.9% to 28% primarily due to more bystander CPR and defibrillator use.
Background And Objectives: Transient ischemic attack (TIA) is associated with a higher short-term incidence of stroke. However, long-term data on this association are lacking. Therefore, this study aimed to determine the long-term incidence of ischemic stroke after TIA according to ABCD score and to identify factors associated with stroke after TIA.
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- The study aimed to determine if high levels of high-sensitivity troponin-T (hs-TnT) in patients with paroxysmal supraventricular tachycardia (PSVT) but no known cardiovascular disease increase the risk of death.
- Researchers reviewed data from 1,203 patients hospitalized from 2013 to 2020, finding that 65.8% had elevated hs-TnT levels.
- Results showed significantly higher short-term mortality (within 30 days) for patients with elevated hs-TnT, but long-term mortality (31-365 days) differences were not significant and may need further study.
Background: Anticoagulation in atrial fibrillation (AF) increases the risk of major bleeding. No predictive model has hitherto provided estimates of the absolute risk for individual patients.
Aim: To predict the individual 1-year risk of major bleeding in patients with AF taking anticoagulants and evaluate the importance of individual risk factors.
Aims: Iron deficiency (ID) is prevalent in chronic heart failure (HF) but lacks a consensus definition. This study evaluates the prevalence and the prognostic impact of ID using different criteria on all-cause and cardiovascular mortality, as well as first hospitalization for HF in patients with new-onset chronic HF.
Methods: In this nationwide registry-based cohort, we explored four definitions of ID: the current European Society of Cardiology (ESC) guidelines [ferritin <100 ng/mL or ferritin 100-299 ng/mL and transferrin saturation (TSAT) <20%], ferritin level <100 ng/mL, TSAT < 20% and serum iron ≤13 μmol/L.
Risk of cardiovascular disease (CVD) in patients with classical Hodgkin lymphoma (cHL) undergoing contemporary treatment is unclear. cHL patients ≥ 18 years at diagnosis treated with doxorubicin-containing chemotherapy between 2000 and 2022 were matched 1:5 with comparators on birth year, sex, and Charlson Comorbidity Index at time of matching (score of 0 or ≥ 1). Cause-specific cumulative incidence of a composite of CVDs with corresponding 95% confidence intervals (CIs) were computed with death and lymphoma relapse as competing events (i.
View Article and Find Full Text PDFRisk of developing hyperkalemia in patients with hypertension treated with combination antihypertensive therapy - a retrospective register-based study.
Hypertens Res
January 2025
The risk of hyperkalemia in relation to different combinations of antihypertensive therapy remains to be elucidated. In this Danish register-based study, we aimed to investigate the risk of developing hyperkalemia in relation to different combinations of antihypertensive therapy. Using incidence density matching, we matched a hyperkalemic patient to five normokalemic patients on eGFR groups, age, sex, and time between study entry and date of potassium measurement.
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- Many COPD patients are diagnosed late, often during their first acute exacerbation (AECOPD), which increases mortality risk.
- In a study of over 107,000 patients, those diagnosed in primary care were younger, while those identified in hospitals were older, mostly male, and had more comorbidities.
- Hospital diagnoses were linked to higher one-year mortality rates compared to earlier diagnoses in primary care, emphasizing the importance of timely diagnosis.
Aims: Infections have been associated with acute myocardial infarction (AMI), but differences in risk between infection types and age groups are unclear. This study aims to investigate whether infections are associated with subsequent AMI and whether the risk differs across infection sites and age groups.
Methods: Nationwide registers were used to include 702596 adults hospitalized between 1987-2018 with either; pneumonia (n=344319), urinary tract infection (UTI) (n=270101), soft tissue/bone infection (n=66718), central nervous system infection (CNS) (n=17025), or endocarditis (n=4433).
Background: Chest pain is a frequent cause of health care contacts. We examined the prehospital management, in-hospital discharge diagnoses, and mortality of patients calling a non-emergency and emergency medical service with chest pain.
Methods: The Copenhagen Emergency Medical Services (EMS) consists of a non-emergency medical helpline (calls to 1813) and emergency medical service (1-1-2 calls).
Article Synopsis
- The study aimed to evaluate the risk of developing anemia in older Danish individuals (aged 65 and above) who used low-dose aspirin (LDA) for cardiovascular prevention between 2008 and 2013.
- Using Danish health registers, researchers tracked over 313,000 participants and found that LDA users had a significantly higher incidence of both hematinic deficiency (9.6%) and anemia (5.9%) compared to non-users.
- The results suggest that approximately 6 to 10 out of every 100 older adults using LDA may develop anemia within the first five years of treatment, highlighting the risks associated with LDA usage in this demographic.
Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RA) are increasingly being prescribed in drug-naive patients. We aimed to contrast add-on therapy, adherence, and changes in biomarkers, 1 year after treatment initiation with GLP-1 RA or metformin.
Methods: Using Danish nationwide registers, we included incident GLP-1 RA or metformin users from 2018 to 2021 with glycated hemoglobin (HbA1c) ≥ 42 mmol/mol.
Background: Ongoing opioid treatment can potentially modify symptoms of myocardial infarction (MI) and cause a lack of recognition and treatment delay.
Objectives: The purpose of this study was to examine MI symptoms and the time to hospitalization for patients in ongoing opioid treatment compared to patients without ongoing opioid treatment.
Methods: We evaluated calls to the Copenhagen Emergency Medical Services in Denmark from 2014 to 2018.
Article Synopsis
- Pericardial effusion is a serious condition that can happen after doctors put in heart devices, and it might lead to even worse problems like cardiac tamponade.
- Researchers studied data from over 55,000 patients in Denmark to find out what factors might increase the chances of this happening after getting heart devices like pacemakers.
- They found that certain things, like being female, having heart failure, or the number of leads in the device, can make it more likely to have a problem called procedural pericardial effusion, even though it's pretty rare.
Article Synopsis
- Heart failure (HF) significantly increases the risk of death and hospitalization compared to the general population, especially evident in patients initiating guideline-directed therapy.
- In a study of over 35,000 HF patients matched with non-HF individuals, those with HF had a 13% higher risk of death, 17% higher risk of HF-related hospitalization, and 24% higher risk of non-HF hospitalization over five years.
- The excess risk of death declined with age; for example, a 60-year-old man with HF had a similar five-year death risk to a 75-year-old man without HF, suggesting the need to adjust healthcare resources based on age and comorbidities.
Incidence of Bacteremia in Patients Following Implantation of Cardiac Implantable Electronic Devices: A Danish Nationwide Cohort Study.
Open Forum Infect Dis
September 2024
Article Synopsis
- Bacteremia (SAB) is a serious condition that can lead to high rates of illness and death, especially in patients with cardiac implantable electronic devices (CIEDs), prompting researchers to study its incidence in first-time CIED carriers in Denmark over a 10-year period.
- The study involved 87,257 patients from a national registry who had their first CIED implanted from 2000 to 2020, with a focus on identifying the occurrence of SAB after the procedure and understanding risk factors that contribute to it.
- Results showed that 1.6% of patients developed SAB, with higher risks associated with specific device types and factors such as hemodialysis, previous SAB, liver disease, and demographic
Bacteremia and infective endocarditis following left-sided heart valve surgery.
Eur Heart J Qual Care Clin Outcomes
September 2024
Background And Aims: In patients undergoing heart valve surgery, subsequent bacteremia and infective endocarditis are feared events. Data on the incidence and bacterial microbiological etiology following left-sided heart valve surgery are sparse.
Methods: Between 2010-2021, all patients undergoing left-sided valve surgery were identified using Danish nationwide registries.
Aim: We investigated the associations between motor performance and IQ at 5 years of age and school difficulties and grade point averages (GPAs) at 18 years of age. Additionally, the accuracy of preschool IQ in predicting school difficulties was examined.
Methods: A nationwide follow-up study of children born in 1994-1995 who were <28 weeks of gestation or had a birthweight <1000 g.
Background: Sex- and population-specific 99th percentiles of high-sensitivity cardiac troponin (hs-cTn) are recommended in guidelines although the evidence for a clinical utility is sparse. The DANSPOT trial will investigate the clinical effect of sex- and population-specific 99th percentiles of cTn. We report the 99th percentiles derived from this trial and their dependency on kidney function.
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