Publications by authors named "Christian Silva Simoneti"
Background: Endotoxin from Gram-negative bacteria are found in different concentrations in dust and on the ground of laboratories dealing with small animals and animal houses.
Methods: Cross-sectional study performed in workplaces of two universities. Dust samples were collected from laboratories and animal facilities housing rats, mice, guinea pigs, rabbits or hamsters and analyzed by the "Limulus amebocyte lysate" (LAL) method.
Article Synopsis
- - The study aimed to assess how allergen levels and various risk factors affect allergic responses, asthma, and bronchial hyperresponsiveness in workers exposed to lab animals across 123 workplaces with 737 subjects.
- - Researchers collected dust samples from labs housing different types of lab animals and compared the allergen exposure between those working with animals and those in non-exposed settings, measuring various health indicators.
- - Results indicated that prolonged exposure (over 2.8 years) to laboratory animals increased the likelihood of developing atopic sensitization, but allergen concentration did not correlate with increased health risks, highlighting duration over concentration as a key factor.