Electrospinning of Crystallizable Polypeptoid Fibers.

A unique fabrication process of low molar mass, crystalline polypeptoid fibers is described. Thermoresponsive fiber mats are prepared by electrospinning a homogeneous blend of semicrystalline poly(N-(n-propyl) glycine) (PPGly; 4.1 kDa) with high molar mass poly(ethylene oxide) (PEO).

Temperature-Triggered Protein Adsorption on Polymer-Coated Nanoparticles in Serum.

The protein corona, which forms on the nanoparticle's surface in most biological media, determines the nanoparticle's physicochemical characteristics. The formation of the protein corona has a significant impact on the biodistribution and clearance of nanoparticles in vivo. Therefore, the ability to influence the formation of the protein corona is essential to most biomedical applications, including drug delivery and imaging.

Poly(α-Peptoid)s Revisited: Synthesis, Properties, and Use as Biomaterial.

Polypeptoids have been of great interest in the polymer science community since the early half of the last century; however, they had been basically forgotten materials until the last decades in which they have enjoyed an exciting revival. In this mini-review, we focus on the recent developments in polypeptoid chemistry, with particular focus on polymers synthesized by the ring-opening polymerization (ROP) of amino acid N-carboxyanhydrides (NCAs). Specifically, we will review traditional monomer synthesis (such as Leuchs, Katchalski, and Kricheldorf) and recent advances in polymerization methods to yield both linear, cyclic, and functional polymers, solution and bulk thermal properties, and preliminary results on the use of polypeptoids as biomaterials (i.

Hofmeister salt effects on the LCST behavior of poly(2-oxazoline) star ionomers.

Effects of pH, ionic strength, and type of salt (variation of anions) on the cloud-point temperature (T(CP)) of thermoresponsive poly(2-ethyl-2-oxazoline) star ionomers are investigated. T(CP) s can be varied in a wide range, from 10 to >95 °C, corresponding with the Hofmeister series and the ionization of the core. Addition of salt weakens the influence of pH.