Publications by authors named "Christian Roux"
Objective: To examine the course of interstitial lung disease associated with rheumatoid arthritis (RA-ILD) in France on treatment with Janus kinase inhibitors (JAKis) using the MAJIK-SFR registry.
Methods: Prospective national multicentre observational study identifying patients with RA-ILD from the MAJIK-SFR registry. Pulmonary assessment data were collected at JAKi initiation and follow-up visits (6 months, 12 months and a median of 21 months postinclusion), including chest high-resolution CT (HRCT), pulmonary function tests (forced vital capacity (FVC) and diffusing capacity of the lungs for carbon monoxide (DLCO)), acute exacerbations of ILD, respiratory infections and lung cancers.
Comparison of two strategies of glucocorticoid withdrawal in patients with rheumatoid arthritis in low disease activity (STAR): a randomised, placebo-controlled, double-blind trial.
Ann Rheum Dis
October 2024
Article Synopsis
- A study compared two methods for stopping glucocorticoids in rheumatoid arthritis patients with low disease activity: replacing prednisone with hydrocortisone or tapering prednisone down gradually.
- The trial included 102 patients and found that after 12 months, 55% in the hydrocortisone group and 47% in the tapering group successfully discontinued glucocorticoids, showing no significant difference between the groups.
- The results indicated that neither strategy was superior for achieving discontinuation, and there were no serious side effects related to adrenal insufficiency observed.
Article Synopsis
- Fibrodysplasia ossificans progressiva (FOP) is a rare disorder causing painful flare-ups and abnormal bone growth, known as heterotopic ossification (HO).
- In a clinical trial, patients receiving the anti-activin A antibody garetosmab experienced fewer severe and lengthy flare-ups compared to those given a placebo, leading to a notable difference in quality of life.
- The study found that 71% of placebo patients had flare-ups linked to new HO lesions, while garetosmab reduced the severity, duration, and frequency of these flare-ups throughout the trial.
Background: Metastases to the bone of aortic sarcoma include osteolytic and nonosteolytic lesions. This study aims to review the clinical symptoms, the sites, and diagnostic methods of bone metastases and to compare the osteolytic and nonosteolytic metastases of patients with aortic sarcoma.
Methods: A systematic search was conducted in PubMed and scientific journals published from 1972 to 2022.
Article Synopsis
- Multiple myeloma (MM) can lead to vertebral fractures (VF) that often resemble benign osteoporotic fractures, but the study focused on patients with smoldering myeloma (SM) and these specific VF types.
- Out of 184 patients, 13 had SM and confirmed osteoporotic VF, with most (92%) progressing to symptomatic MM within a relatively short follow-up period, often characterized by new lytic bone lesions.
- The study found that early progressors had higher serum calcium levels and more VF at diagnosis, suggesting these particular VF may indicate a risk of rapid progression to symptomatic MM rather than being purely age-related osteoporotic fractures, indicating the need for further research on potential early treatment options
Objectives: To determine whether subjective components of disease activity are associated with heterogeneity in opioid prescription in inflammatory rheumatic diseases (IRDs) after accounting for objective inflammatory markers.
Methods: Data from two prospective observational cohorts of early IRDs (ESPOIR for rheumatoid arthritis (RA) and DESIR for spondyloarthritis (SpA)) were included. Opioid prescription duration (converted to monthly binary opioid prescription), disease activity (Disease activity score 28 (DAS28) for RA; Axial spondyloarthritis disease activity score-C-reactive protein (ASDAS-CRP) for SpA) and its components were measured respectively at 13 and 9 occasions spanning 10- and 6-years of follow-up.
Background: This manuscript provides a summary of the current evidence to support the criteria for diagnosing a child or adult with hypophosphatasia (HPP). The diagnosis of HPP is made on the basis of integrating clinical features, laboratory profile, radiographic features of the condition, and DNA analysis identifying the presence of a pathogenic variant of the tissue nonspecific alkaline phosphatase gene (ALPL). Often, the diagnosis of HPP is significantly delayed in both adults and children, and updated diagnostic criteria are required to keep pace with our evolving understanding regarding the relationship between ALPL genotype and associated HPP clinical features.
View Article and Find Full Text PDFArticle Synopsis
- Hypophosphatasia (HPP) is a rare metabolic disorder caused by low activity of the alkaline phosphatase enzyme, linked to mutations in the ALPL gene, and can present in various forms from severe neonatal cases to mild adult manifestations.
- Diagnosing HPP in adults is challenging due to mild and non-specific symptoms, leading to underdiagnosis or misdiagnosis, especially among clinicians unfamiliar with the condition.
- The HPP International Working Group analyzed existing studies to identify effective diagnostic criteria, ultimately proposing four major and five minor criteria for diagnosing HPP in adults, advocating for a combined approach in diagnosis.
Hypophosphatasia (HPP) is a rare inborn error of metabolism that presents variably in both age of onset and severity. HPP is caused by pathogenic variants in the ALPL gene, resulting in low activity of tissue nonspecific alkaline phosphatase (TNSALP). Patients with HPP tend have a similar pattern of elevation of natural substrates that can be used to aid in diagnosis.
View Article and Find Full Text PDFArticle Synopsis
- - Fibrodysplasia ossificans progressiva (FOP) is a rare condition that causes painful heterotopic ossification in connective tissues, leading to disability.
- - In the LUMINA-1 phase 2 trial, adults with FOP were given either garetosmab (an activin A-blocking antibody) or a placebo over two 28-week periods, focusing on safety and effects on HO lesions.
- - Although the primary efficacy endpoint was not met in the first period, garetosmab significantly reduced the development of new HO lesions in the second period compared to placebo, with ongoing investigations into its effectiveness.
Objectives: The efficacy of anti-IL-6 receptors such as tocilizumab (TCZ) was demonstrated in patients with PMR in two recent randomized controlled trials. The objective of this multicentre retrospective study was to assess the efficacy of TCZ in PMR patients requiring glucocorticoid (GC)-sparing treatment, as well as different strategies for TCZ withdrawal.
Methods: We conducted a multicentre study in French tertiary healthcare departments for patients with PMR.
Purpose: To evaluate the efficacy and safety of embolization of hyperemic synovial tissue for the treatment of persistent pain after total knee arthroplasty (TKA).
Materials And Methods: Twelve patients with persistent pain after TKA were enrolled in this prospective, single-center pilot study. Genicular artery embolization (GAE) was performed using 75-μm spherical particles.
Development of Spinal Enthesopathies in Adults With X-linked Hypophosphatemia.
J Clin Endocrinol Metab
November 2023
Context: Musculoskeletal complications are the main manifestations in adults with X-linked hypophosphatemia (XLH). Enthesopathy significantly impairs quality of life.
Objective: To identify the risk factors associated with the development and progression of spinal enthesopathies in adults with XLH.
Oxytocin (OT), a neuropeptide best known for its role in emotional and social behaviors, has been linked to osteoarthritis (OA). This study aimed to investigate the serum OT level in hip and/or knee OA patients and to study its association with disease progression. Patients from the KHOALA cohort with symptomatic hip and/or knee OA (Kellgren and Lawrence (KL) scores of 2 and 3) and follow-up at 5 years were included in this analysis.
View Article and Find Full Text PDFIntroduction: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) have been characterized with the use of oral bisphosphonates in osteoporosis and zoledronate in oncology. Uncertainties remain, though, with the occurrence of BRONJ related to the use of zoledronate in osteoporosis.
Objectives: We aimed to estimate the incidence and characterize the risk factors of zoledronate-associated BRONJ in osteoporosis as compared with oral bisphosphonates in real life setting.
Introduction: Context: The development of knee osteoarthritis (OA) after anterior cruciate ligament (ACL) injury is now widely recognized. The impact of surgical or non-surgical management on the development of post-traumatic osteoarthritis is still debated in the medical community.Here, we present a meta-analysis comparing the impact of surgical or non-surgical management of ACL injuries on the development of knee OA.
View Article and Find Full Text PDFArticle Synopsis
- This study looks at how well different osteoporosis treatments work to prevent fractures in postmenopausal women.
- They analyzed many clinical trials from different sources, focusing on various treatments like bisphosphonates and romosozumab.
- The results showed that some treatments were better at protecting against fractures than others, with bisphosphonates and certain hormone treatments being more effective.
Obesity is a complex disease highly related to diet and lifestyle and is associated with low amount of thermogenic adipocytes. Therapeutics that regulate brown adipocyte recruitment and activity represent interesting strategies to fight overweight and associated comorbidities. Recent studies suggest a role for several fatty acids and their metabolites, called lipokines, in the control of thermogenesis.
View Article and Find Full Text PDF