Publications by authors named "Christian Ricardo Sanchez-Mendoza"
Oxidative stress (OS) plays an essential role in the pathophysiology of Duchenne muscular dystrophy (DMD). However, the actors that regulate OS need to be better studied. We aimed to evaluate whether NFE2-like bZIP transcription factor 2 (Nrf2), glutathione, malondialdehyde (MDA), and protein carbonyl concentrations change according to the disease severity in DMD patients.
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- This study investigates the relationship between certain circulating microRNAs (dystromiRs and oxidative stress-related miRNAs) and muscle injury in patients with Duchenne muscular dystrophy (DMD).
- Researchers analyzed 24 DMD patients, measuring various indicators of muscle function, metabolic parameters, and serum microRNA levels.
- Results showed that non-ambulatory DMD patients had lower levels of these microRNAs compared to ambulatory patients, indicating that muscle injury progression correlates with decreasing expression of these miRNAs, thus enhancing our understanding of DMD's natural history.