Interactions between Mutant Bacterial Lipopolysaccharide (LPS-Ra) Surface Layers: Surface Vesicles, Membrane Fusion, and Effect of Caand Temperature.

Lipopolysaccharides (LPS) are a major component of the protective outer membrane of Gram-negative bacteria. Understanding how the solution conditions may affect LPS-containing membranes is important to optimizing the design of antibacterial agents (ABAs) which exploit electrostatic and hydrophobic interactions to disrupt the bacteria membrane. Here, interactions between surface layers of LPS (Ra mutants) in aqueous media have been studied using a surface force apparatus (SFA), exploring the effects of temperature and divalent Ca cations.

Hierarchical Surface Patterns upon Evaporation of a ZnO Nanofluid Droplet: Effect of Particle Morphology.

Surface structures with tailored morphologies can be readily delivered by the evaporation-induced self-assembly process. It has been recently demonstrated that ZnO nanorods could undergo rapid chemical and morphological transformation into 3D complex structures of Zn(OH) nanofibers as a droplet of ZnO nanofluid dries on the substrate via a mechanism very different from that observed in the coffee ring effect. Here, we have investigated how the crystallinity and morphology of ZnO nanoparticles would affect the ultimate pattern formation.

Structure of lipid multilayers via drop casting of aqueous liposome dispersions.

Understanding the structure of solid supported lipid multilayers is crucial to their application as a platform for novel materials. Conventionally, they are prepared from drop casting or spin coating of lipids dissolved in organic solvents, and lipid multilayers prepared from aqueous media and their structural characterisation have not been reported previously, due to their extremely low lipid solubility (i.e.

Normal development in mice over-expressing the intracellular domain of DLL1 argues against reverse signaling by DLL1 in vivo.

The Notch signaling pathway mediates the direct communication between adjacent cells and regulates multiple developmental processes. Interaction of the Notch receptor with its ligands induces the liberation of the intracellular portion of Notch (NICD) referred to as regulated intramembraneous proteolysis (RIP). NICD translocates to the nucleus, and by complexing with the DNA binding protein RBPjκ and other cofactors activates transcription of bHLH genes.