Publications by authors named "Christian R Rodrigues"
Article Synopsis
- - The study focuses on the
- Echinococcus granulosus
- species, which causes cystic echinococcosis, investigating how small extracellular vesicles (sEVs) from the parasite interact with host immune cells and affect disease progression, especially during pharmacological treatments.
- - Researchers isolated and characterized sEVs from both untreated and drug-treated parasites, revealing over 500 proteins within these vesicles that are associated with immune response regulation and drug action.
- - Findings indicate that sEVs derived from treated parasites, particularly those treated with metformin and albendazole sulfoxide, enhance the immune response in mouse dendritic cells, raising levels of pro-inflammatory cytokines such as IL-12, IL-
Alveolar echinococcosis (AE) is a severe disease caused by Echinococcus multilocularis. Its chemotherapeutic treatment is based on benzimidazoles, which are rarely curative and cause several adverse effects. Therefore, it is necessary to develop alternative and safer chemotherapeutic strategies against AE.
View Article and Find Full Text PDFMetformin (Met) is an anti-hyperglycemic and potential anti-cancer agent which may exert its anti-proliferative effects via the induction of energetic stress. In this study we investigated the in vitro and in vivo efficacy of Met against the larval stage of Echinococcus granulosus. Metformin showed significant dose- and time-dependent killing effects on in vitro cultured protoscoleces and metacestodes.
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