Publications by authors named "Christian Quinones"
Background: Parafalcine subdural hematomas (pSDHs) are a subtype of subdural hematoma (SDH) that occur most frequently in older patients after blunt trauma. The literature primarily describes two clinical courses for patients with pSDH: those who are neurologically intact with stable examinations and imaging and those with focal deficits, with or without hematoma progression. Surgical management is undoubtedly required for the latter group; however, there are no evidence-based guidelines specifically for pSDH.
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- The article provides a comprehensive overview for U.S. clinicians on assessing and managing spinal cord injuries (SCI), covering initial care, acute management, complications, and future research.
- Initial care focuses on minimizing secondary injuries through neurological evaluations and stabilizing vital functions, especially for patients with serious neurological decline.
- The document also highlights emerging therapies and biomarkers that could improve outcomes and predictions for recovery, suggesting a multidisciplinary approach is essential for holistic patient care.
Article Synopsis
- Awake surgery for the spine (ASFS) offers a promising alternative to general anesthesia in neurosurgery, which has mainly focused on cranial procedures.
- ASFS is gaining traction among spine surgeons due to early studies showing positive outcomes and addressing the risks associated with general anesthesia, such as postoperative complications.
- This narrative review will cover the history, mechanisms, protocols, and current trends of using ASFS in spine surgery.
At the molecular level, the circadian clock is regulated by a time delayed transcriptional-translational feedback loop in which the core proteins interact with each other rhythmically to drive daily biological rhythms. The C-terminal domain of a key clock protein PER2 (PER2c) plays a critically important role in the loop, not only for its interaction with the binding partner CRY proteins but also for the CRY/PER complex's translocation from the cytosol to the nucleus. Previous circular dichroism (CD) spectroscopic studies have shown that mouse PER2c (mPER2c) is less structured in solution by itself but folded into stable secondary structures upon interaction with mouse CRYs.
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