Publications by authors named "Christian Puttinger"
Introduction: Itch is one of the most burdensome symptoms in epidermolysis bullosa (EB), indicating a hitherto unmet therapeutic need. This review leverages existing data on efficacy of itch treatment in EB to support sound decision making.
Methods: A systematic literature search was performed on 29 March 2022.
Background: Cytoplasmic mislocalization and aggregation of TAR DNA-binding protein-43 (TDP-43) is a hallmark of the amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD) disease spectrum, causing both nuclear loss-of-function and cytoplasmic toxic gain-of-function phenotypes. While TDP-43 proteinopathy has been associated with defects in nucleocytoplasmic transport, this process is still poorly understood. Here we study the role of karyopherin-β1 (KPNB1) and other nuclear import receptors in regulating TDP-43 pathology.
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- * The study involved 18 MS patients, measuring specific antibody levels against some common viruses and toxins before and after CLAD treatment at 12 and 24 months, finding minimal changes (loss of protection in less than 1%).
- * Results showed that while CLAD reduced certain immune cells' counts significantly over time, it did not lower antibody levels or affect the body's existing immunity to common pathogens.