Publications by authors named "Christian Peter Both"
Background: Cuffed endotracheal tubes (cETT) pose the potential advantage of an infrequent need for reintubation in pediatric patients compared to uncuffed tubes. The aim of this study was to investigate tube exchange rates using second generation Microcuff® pediatric endotracheal tubes (PET) with an adapted sizing recommendation in a large single institution cohort of children and to identify potential variables associated with an elevated risk of tube exchange.
Methods: Patient data obtained from the electronic patient data management system of the Department of Anesthesia, University Children's Hospital Zurich, Switzerland, were retrospectively assessed for demographic and anthropometric information, size of the internal tube diameter used for positive pressure ventilation and divergence from the size recommendation chart.
Article Synopsis
- Sudden infant death syndrome (SIDS) remains a major cause of infant mortality in developed nations, with potential links to genetic variants affecting the respiratory control system.* -
- In examining the DNA of 155 SIDS cases, researchers identified possible harmful genetic variants related to respiratory chemoreception in only 3% of the cases, with some variants showing effects on potassium channels that help regulate breathing.* -
- The findings suggest that while genetic factors may contribute to SIDS risk, they likely play a minor role in the broader, complex causes of the syndrome, aligning with prior studies on the topic.*
Background: Over the last decade, cuffed endotracheal tubes are increasingly used in pediatric anesthesia and also in pediatric intensive care. However, the smaller inner diameter of cuffed endotracheal tubes and, implicitly, the increased endotracheal tube resistance is still a matter of debate.
Aims: This in vitro study investigated work of breathing and inspiratory airway pressures in cuffed and uncuffed endotracheal tubes and the impact of pressure support ventilation and automatic tube compensation.