[The introduction of antipsychotics in the neurological psychiatric hospital of the University of Leipzig and their effects on other forms of therapy, the length of stay and transferrals].

Aim: The impacts of the introduction of antipsychotics on psychiatric care in a clinic were investigated for the first time, specifically in the Neurological and Psychiatric Clinic of the University of Leipzig from 1946 to 1965.

Research Questions: When and which antipsychotics were first used, to what extent and how did this affect the use of traditional forms of therapy?

Material And Methods: According to psychopathological criteria, 306 cases were selected from the database of patient records from the hospital archive and systematically reviewed with respect to the research question.

Results: The use of antipsychotics began in 1953 and subsequently with increasing frequency and duration.

Association of the X-chromosomal genes TIMP1 and IL9R with rheumatoid arthritis.

Objective: Rheumatoid arthritis (RA) is an inflammatory joint disease with features of an autoimmune disease with female predominance. Candidate genes located on the X-chromosome were selected for a family trio-based association study.

Methods: A total of 1452 individuals belonging to 3 different sample sets were genotyped for 16 single-nucleotide polymorphisms (SNP) in 7 genes.