High positive end-expiratory pressure ventilation mitigates the progression from unilateral pulmonary contusion to ARDS: An animal study.

Background: Pulmonary contusion (PC) is common in severely traumatized patients and can lead to respiratory failure requiring mechanical ventilation (MV). Ventilator-induced lung injury (VILI) might aggravate lung damage. Despite underrepresentation of trauma patients in trials on lung-protective MV, results are extrapolated to these patients, potentially disregarding important pathophysiological differences.

Characteristics of different cathodic arc deposition coatings on CoCrMo for biomedical applications.

Coatings of endoprostheses are used to improve the tribological performance of arthroplasties. A major challenge for the successful use of these coatings, however, is a stable layer adhesion, a smooth surface, as well as a reduction in droplet formation during the coating process. Explants with commercially available coatings were investigated to assess surface/layer defects and adhesion properties.