Publications by authors named "Christian Mazzeo"
Background: Despite substantial research, the mechanisms behind stress Tako-tsubo cardiomyopathy (TTC) remain rather elusive.
Objective: The purpose of this paper was to provide a detailed review of the mainstream factors underlying the pathophysiology of TTC, highlighting the novel contributions of molecular pathology and in-vivo molecular imaging.
Methods: A careful literature review selected all papers discussing TTC, specifically those providing novel insights from myocardial pathology and cardiac molecular imaging.
Neurobiological Dysfunctional Substrates for the Self-Medication Hypothesis in Adult Individuals with Attention-Deficit Hyperactivity Disorder and Cocaine Use Disorder: A Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography Study.
Brain Connect
September 2023
Article Synopsis
- The study explores the link between adult ADHD and cocaine use disorder (CoUD), focusing on the self-medication hypothesis, which suggests individuals use substances to manage ADHD symptoms.
- It involved 19 ADHD-CoUD patients and 16 CoUD patients, examining brain metabolism through F-FDG PET scans to identify differences in metabolic activity and connectivity related to both conditions.
- Findings showed ADHD-CoUD patients had distinct metabolic patterns in certain brain regions, indicating unique neurobiological factors that might support self-medication, suggesting differing underlying mechanisms between ADHD-CoUD and CoUD alone.
Purpose: To investigate changes in sympathetic activity, perfusion, and left ventricular (LV) functionality in takotsubo cardiomyopathy (TTC) patients from onset (T) to post-onset conditions at 1 month (T), 1-2 years (T, T).
Methods: Twenty-two patients (70 ± 11 years) underwent serial gated single photon emission tomography (G-SPECT) studies with I-mIBG and Tc-Sestamibi. Statistics were performed using ANOVA/Sheffé post-hoc, correlation test, and receiver operating characteristic (ROC) curve analysis (p < 0.
Purpose: To assess changes in social and neuro-cognition and regional cerebral blood flow (rCBF) in schizophrenic patients with psychotic syndrome treated with Social Skill Training (SST).
Methods: 17 patients underwent two high resolution rCBF SPECT at rest before and after a one-year treatment with SST. Patients were assessed using a neuropsychological evaluation (W.