Publications by authors named "Christian Mangala"
Article Synopsis
- High-risk genotypes of Human Papillomavirus (HR-HPV) are linked to 90% of cervical cancer cases globally, and are prevalent among women in Gabon, with a study revealing a 26.1% overall HPV infection rate.
- The study involved 399 women and found that the prevalence of HR-HPV was 24.8%, with the most common types including HPV-16, 18, and 52; it also reported a significant rate of multiple HPV infections at 29.8%.
- A strong correlation was established between HPV viral load and squamous cell inflammation, highlighting the need for early screening to manage HR-HPV infections effectively.
Background: Surveillance of HIV-1 pre-treatment drug resistance (PDR) is essential for ensuring the success of first-line antiretroviral therapy (ART). Beside population-based surveys, sentinel surveillance of PDR and circulating HIV-1 clades in specific populations such as blood donors could efficiently inform decision-making on ART program. We therefore sought to ascertain HIV-1 residual infection, the threshold of PDR and viral diversity among recently-diagnosed blood donors in Gabon.
View Article and Find Full Text PDFPrevalence and factors associated with transfusion-transmissible infections (HIV, HBV, HCV and Syphilis) among blood donors in Gabon: Systematic review and meta-analysis.
PLoS One
August 2024
Background: Transfusion-transmissible infections (TTIs) remain a major public health problem in countries with limited resources, particularly in Gabon. Complete information on the prevalence in Gabon of the main TTIs among blood donors is still lacking in the national context. The purpose of this systematic review and meta-analysis was to determine the prevalence and factors associated with TTIs among blood donors in Gabon.
View Article and Find Full Text PDFDetection of drug resistance mutations (DRMs) and HIV-1 subtypes ensures effective therapeutic management for HIV-infected individuals. In Gabon, data on DRMs are very little available in the population of people living with HIV and also among voluntary HIV-positive blood donors. This study aimed to study subtypes and DRMs in HIV-1-positive volunteer blood donors in Gabon.
View Article and Find Full Text PDFBackground: The high endemicity of transfusion-transmissible infections (TTIs) in sub-Saharan Africa is a real public health problem. To reduce the risk of HIV transmission through blood donation, the NBTC of Gabon has launched in recent years a reorganization of its blood transfusion system. This study aims to characterize the molecular strains of HIV-1 circulating in donors and to estimate the risk of viral transmission.
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