Publications by authors named "Christian Lagares-Linares"
Article Synopsis
- * The study identifies a specific microglial state that responds to type I interferon (IFN-I) and actively engulfs neurons during the early postnatal development of the somatosensory cortex.
- * Alterations in IFN-I signaling impact microglial function, leading to neuronal damage and increased excitatory neurons, which may contribute to heightened sensitivity to touch, highlighting the importance of microglia in brain development and homeostasis.
Article Synopsis
- - Microglia, the brain's resident immune cells, play a crucial role in engulfing neurons during brain development, especially influenced by a distinct subset responsive to Type I interferon (IFN-I).
- - This specific microglial response was significantly increased after sensory deprivation in young mice, indicating their involvement in neural circuit remodeling.
- - Disrupting IFN-I signaling led to dysfunctional microglia and increased neuron stress, demonstrating IFN-I's essential role in maintaining proper neuronal health and development in the brain.
