Matching algorithms for assigning orthologs after genome duplication events.

In this paper, we introduce and analyze two graph-based models for assigning orthologs in the presence of whole-genome duplications, using similarity information between pairs of genes. The common feature of our two models is that genes of the first genome may be assigned two orthologs from the second genome, which has undergone a whole-genome duplication. Additionally, our models incorporate the new notion of duplication bonus, a parameter that reflects how assigning two orthologs to a given gene should be rewarded or penalized.

Parameterized Algorithmics for Finding Exact Solutions of NP-Hard Biological Problems.

Fixed-parameter algorithms are designed to efficiently find optimal solutions to some computationally hard (NP-hard) problems by identifying and exploiting "small" problem-specific parameters. We survey practical techniques to develop such algorithms. Each technique is introduced and supported by case studies of applications to biological problems, with additional pointers to experimental results.

A graph modification approach for finding core-periphery structures in protein interaction networks.

The core-periphery model for protein interaction (PPI) networks assumes that protein complexes in these networks consist of a dense core and a possibly sparse periphery that is adjacent to vertices in the core of the complex. In this work, we aim at uncovering a global core-periphery structure for a given PPI network. We propose two exact graph-theoretic formulations for this task, which aim to fit the input network to a hypothetical ground truth network by a minimum number of edge modifications.

Partitioning Biological Networks into Highly Connected Clusters with Maximum Edge Coverage.

A popular clustering algorithm for biological networks which was proposed by Hartuv and Shamir identifies nonoverlapping highly connected components. We extend the approach taken by this algorithm by introducing the combinatorial optimization problem Highly Connected Deletion, which asks for removing as few edges as possible from a graph such that the resulting graph consists of highly connected components. We show that Highly Connected Deletion is NP-hard and provide a fixed-parameter algorithm and a kernelization.

An analytical approach to network motif detection in samples of networks with pairwise different vertex labels.

Network motifs, overrepresented small local connection patterns, are assumed to act as functional meaningful building blocks of a network and, therefore, received considerable attention for being useful for understanding design principles and functioning of networks. We present an extension of the original approach to network motif detection in single, directed networks without vertex labeling to the case of a sample of directed networks with pairwise different vertex labels. A characteristic feature of this approach to network motif detection is that subnetwork counts are derived from the whole sample and the statistical tests are adjusted accordingly to assign significance to the counts.

Parameterized algorithmics for finding connected motifs in biological networks.

We study the NP-hard LIST-COLORED GRAPH MOTIF problem which, given an undirected list-colored graph G = (V, E) and a multiset M of colors, asks for maximum-cardinality sets S ⊆ V and M' ⊆ M such that G[S] is connected and contains exactly (with respect to multiplicity) the colors in M'. LIST-COLORED GRAPH MOTIF has applications in the analysis of biological networks. We study LIST-COLORED GRAPH MOTIF with respect to three different parameterizations.