[Subacute parkinsonism as first symptom of primary CNS lymphoma].

Secondary parkinsonism due to cerebral neoplasia is a rare condition. We present a case report of a 73-year-old woman with three weeks of progressing right-sided parkinsonism. Cerebral MRI arouse suspicion of left-sided primary CNS-lymphoma in the left basal ganglia.

Typical Versus Atypical Antipsychotics for Acute Mania.

Background: Mania is challenging to treat. Typical antipsychotics may be more efficient compared with atypical antipsychotics, however, with unfavorable side effects.

Study Question: To investigate the courses of acute manic episodes and correlations between changes of severity during manic episodes and type of antipsychotic treatment.

A dual inhibitor of FAAH and TRPV1 channels shows dose-dependent effect on depression-like behaviour in rats.

Objective: The cannabinoid receptor 1 (CB1) and transient receptor potential cation channel subfamily V member 1 (TRPV1) are proposed to mediate opposite behavioural responses. Their common denominator is the endocannabinoid ligand anandamide (AEA), which is believed to mediate antidepressant-like effect via CB1-R stimulation and depressive-like effect via TRPV1 activation. This is supposed to explain the bell-shaped dose-response curve for anandamide in preclinical models.