Publications by authors named "Christian Kieser"

Article Synopsis
  • Two-photon microscopy (2PM) is a key technique in biology for examining intact tissues, but imaging depth is usually restricted to 600-800 μm due to scattering in adult mammalian tissues like mouse brains.
  • * Researchers aimed to enhance imaging depth by utilizing shortwave near-infrared (SWIR) light, which has faced challenges due to the lack of suitable detectors and probes.
  • * This study introduces a new array of superconducting nanowire single-photon detectors (SNSPDs) that, combined with specific fluorescent dyes, enables imaging depths greater than 1.1 mm in mouse brains, representing a significant advancement in deep tissue imaging technology.
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Modern microscopy relies increasingly on microscope automation to improve throughput, ensure reproducibility or observe rare events. Automation requires computer control of the important elements of the microscope. Furthermore, optical elements that are usually fixed or manually movable can be placed on electronically-controllable elements.

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Background: Over the past 20 years the importance of treatment of people with mental and neurological disorders has greatly increased. Parallel to this development it has become more difficult to attract young physicians to this field. The aim of this study was to examine the development of the number of physicians specialized in the care of patients suffering from neurological, mental and psychosomatic disorders with special consideration of the age structure.

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This study provides for the first time a comprehensive overview of the state-of-the-practice of clinical ethics consultation in German psychiatric hospitals. Structures for ethics counselling were available in only 57 % of the hospitals. In about one third of the participating hospitals, structures of ethics counselling had not yet been considered or were actively dismissed.

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X-ray free-electron lasers (FELs) enable crystallographic data collection using extremely bright femtosecond pulses from microscopic crystals beyond the limitations of conventional radiation damage. This diffraction-before-destruction approach requires a new crystal for each FEL shot and, since the crystals cannot be rotated during the X-ray pulse, data collection requires averaging over many different crystals and a Monte Carlo integration of the diffraction intensities, making the accurate determination of structure factors challenging. To investigate whether sufficient accuracy can be attained for the measurement of anomalous signal, a large data set was collected from lysozyme microcrystals at the newly established `multi-purpose spectroscopy/imaging instrument' of the SPring-8 Ångstrom Compact Free-Electron Laser (SACLA) at RIKEN Harima.

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Objective: Actual codes for operations and procedures (OPS) in psychiatry and psychosomatics should map cost separating therapeutic activities so far defined in Germany by the normative specifications of the psychiatry staff enactment (PsychPV). OPS codes should also allow re-estimating underlying therapy times.

Method: Therapeutic activities of the PsychPV fulfilling the minimal criteria of the OPS definition were classified as multiples of a therapeutic 25 minute unit.

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Issue: In psychiatric and psychotherapeutic clinics that are responsible for supplying care for a region, how often are patients transferred to forensic psychiatric hospitals? Is there a tendency to "send off" aggressive or threatening patients as quickly as possible?

Method: In the psychiatric and psychotherapeutic clinic responsible for the Berlin's Neukölln district, for one year (2000) all patients who committed a severe criminal offence immediately before or during their in-patient treatment were registered for observation in 2000. The steps of investigation and further legal consequences were recorded.

Results: During the period of observation, 0.

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Issue: The results of an inquiry about the difficulties of companionship between smokers and non-smokers in psychiatric wards are presented.

Method: Patients stated at the end of their treatment in a routine inquiry, by now focused on the issue of smoking, how they felt about the organization of their living together within the wards. Smokers have been additionally asked whether they would have preferred to be abstinent of tobacco and whether they missed supplementary therapy offers.

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