Publications by authors named "Christian I Rude"
Toxicol Sci
November 2024
Article Synopsis
- Polycyclic aromatic hydrocarbons (PAHs) are diverse environmental compounds known for their varying toxic effects, often activating the aryl hydrocarbon receptor (AHR) and influencing gene expression, but their mechanisms can differ.
- The study specifically examined retene, which causes developmental toxicity in zebrafish by activating Ahr2 through its metabolites, rather than directly activating the AHR.
- Research found that the cyp1a enzyme plays a key role in the toxicity of retene, with cyp1a-null zebrafish showing heightened sensitivity, while exposure timing and metabolite presence were critical for understanding the toxicity's onset.
Article Synopsis
- Passive sampling devices combined with zebrafish toxicity tests effectively detect harmful non-polar organic mixtures in environmental sites.
- In a study of two locations in Portland Harbor, higher toxicity was noted at river mile 6.5W, linked to specific malformations in zebrafish development.
- RNA sequencing revealed significant gene expression changes due to exposure, suggesting that while some effects stem from known chemicals, other unidentified contaminants may also contribute to toxicity.
