Publications by authors named "Christian Hidalgo"

Article Synopsis
  • Liver fluke infection, caused by Fasciola hepatica, is a significant parasitic zoonotic disease impacting both humans and animals, with important health implications.
  • This study offers the first genetic analysis of F. hepatica in Chile, emphasizing variations in the complete mitochondrial gene cox1 among samples from cattle and horses.
  • Findings reveal that using full-length genetic sequences increases the identification of unique haplotypes, suggesting that greater sequencing efforts are necessary to accurately assess genetic diversity and improve disease control strategies.
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Cystic echinococcosis (CE) is a zoonotic disease caused by the tapeworm sensu lato (s.l). In the intermediate host, this disease is characterized by the growth of cysts in viscera such as liver and lungs, inside of which the parasite develops to the next infective stage known as protoscoleces.

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Background: The COVID-19 pandemic, caused by SARS-CoV-2 infection, has become the most devastating zoonotic event in recent times, with negative impacts on both human and animal welfare as well as on the global economy. Although SARS-CoV-2 is considered a human virus, it likely emerged from animals, and it can infect both domestic and wild animals. This constitutes a risk for human and animal health including wildlife with evidence of SARS-CoV-2 horizontal transmission back and forth between humans and wild animals.

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We report a 47-year-old male with a severe disease caused by COVID-19, who required mechanical ventilation for 18 ays. During the hospital stay he received dexamethasone and anticoagulation with heparin. After discharge a new chest CT scan showed homogeneous hypo vascular enlargement of both adrenal glands, not present in the initial imaging studies.

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Introduction: Project-based learning (PjBL) is a teaching methodology designed to engage students in solving real-world problems, acknowledging that students are active agents of their learning process. This methodology has historically been popular in architecture and industrial sciences; however, its use in teaching veterinary anatomy is scarcely published.

Methods: Using information and communication technologies, the PjBL methodology was implemented in a first-year veterinary anatomy course.

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Cystic echinococcosis is a zoonotic disease caused by the metacestode of Echinococcus granulosus sensu lato. The disease is characterized by the development of cystic structures inside viscera of the intermediate host, mainly liver and lungs. These cysts are formed by three layers: germinal, laminated, and adventitial layer, the latter being the local host immune response.

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Cystic echinococcosis is a widespread zoonosis caused by the larval stage of the tapeworm Echinococcus granulosus. In intermediary hosts, two types of echinococcal cysts can be found: fertile, which produce protoscoleces, the infective form of the parasite to dogs; and infertile, that do not present protoscoleces and therefore are not able to continue with the parasite life cycle. The adventitial layer, the local immune response against the cyst, plays an important role in cyst fertility.

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E. granulosus is a cestode that causes Cystic Echinococcosis (CE), a zoonotic disease with worldwide presence. The immune response generated by the host against the metacestode induces a permissive Th2 response, as opposed to pro-inflammatory Th1 response.

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Polyparasitism occurs when animals harbour multiple parasites concomitantly. It is a common occurrence but is generally understudied in wild and domestic animals. Fasciola hepatica and Echinococcus granulosus, which are helminths of ungulates, frequently coinfect cattle.

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Article Synopsis
  • - Cystic echinococcosis, caused by the Echinococcus granulosus species complex, is a widespread disease impacting both humans and animals, particularly evident in regions like Chile.
  • - A study identified 16 different haplotypes of E. granulosus s.s. from 66 cysts across 10 infected cattle and sheep, with individual animals hosting up to five distinct haplotypes simultaneously.
  • - No clear relationship was found between haplotype type and characteristics such as cyst fertility or size, indicating high molecular diversity and suggesting that multiple haplotypes could indicate hosts from hyperendemic areas.
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Cystic echinococcosis is a worldwide zoonosis caused by the cestode . Two types of hydatid cysts occur in intermediate hosts: fertile cysts that generate protoscoleces from the germinal layer of the cyst, and infertile cysts that do not produce protoscoleces and are unable to continue the life cycle of the parasite. The adventitial layer, a host-derived fibrous capsule surrounding the hydatid cyst, is suggested to play an important role in local immune regulation during infection and in fertility of the cysts.

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Background: Cystic echinococcosis is caused by the metacestode of the zoonotic flatworm Echinococcus granulosus. Within the viscera of the intermediate host, the metacestode grows as a unilocular cyst known as hydatid cyst. This cyst is comprised of two layers of parasite origin: germinal and laminated layers, and one of host origin: the adventitial layer, that encapsulates the parasite.

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Background: Natural parasite infection occurs in wild and domestics animals with more than one parasite species at the same time, generating an infection called polyparasitism. Cystic echinococcosis reports are usually based only on infection with Echinoccocus granulosus leaving aside other internal parasitoses that could modulate both the immune response and pathogenesis of the natural infection. Fasciola hepatica is another cosmopolitan parasite in ruminants with a similar distribution to E.

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Purpose: The aim of this study is to evaluate in vivo the level of apoptosis in human rotator cuff tears and the relationship it might have with tendon degeneration.

Methods: Rotator cuff biopsies from 19 male and female patients, ages between 38 and 68 years, with and without previous corticosteroid infiltrations were collected via arthroscopy. Biopsies from seven patients with healthy rotator cuffs were used as a control group.

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Article Synopsis
  • - Cystic echinococcosis (CE) is a parasitic disease caused by Echinococcus granulosus s.l. and is prevalent in cattle in central Chile, with an infection rate of 18.84%, consistent with data from the last 30 years in the Santiago area.
  • - The majority of cysts were found in the lungs (51%), with some found in the liver and lungs together (30%), and others only in the liver (19%).
  • - Molecular analysis identified E. granulosus s.s. as the dominant species in the cattle population, while E. ortleppi was detected for the first time in Chile, suggesting a need for further research into the genetic characteristics and
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Echinococcus granulosus protoscolex proteins were separated using two-dimensional electrophoresis and then identified using mass spectrometry; we identified 61 proteins, 28 which are newly described of which 4 could be involved in hydatid cyst fertility molecular mechanisms.

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Knowledge about the underlying mechanisms, particularly the signaling pathways that account for muscle growth in vivo in early vertebrates is still scarce. Fish (Paralichthys adspersus) were fasted for 3weeks to induce a catabolic period of strong muscle atrophy. Subsequently, fish were refed for 2weeks to induce compensatory muscle hypertrophy.

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Hydatidosis is an important zoonotic disease of worldwide distribution, causing important health problems to humans and major economical losses in infected livestock. Echinococcus granulosus, the etiological agent of hydatid disease, induces a humoral immune response in the intermediate host (human and herbivorous) against hydatid cyst antigens. Specifically, IgGs are found in the laminar and germinal layers and inside the lumen of fertile and infertile hydatid cysts.

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