Antigen-dependent competition shapes the local repertoire of tissue-resident memory CD8+ T cells.

Tissue-resident memory CD8 T cells (T) constitute a major component of the immune-surveillance system in nonlymphoid organs. Local, noncognate factors are both necessary and sufficient to support the programming of T cell fate in tissue-infiltrating T cells. Recent evidence suggests that TCR signals received in infected nonlymphoid tissues additionally contribute to T cell formation.