Is a computer-based measurement method superior to a recommended manual method by the ROHO(®) Group to assess pressure in the sitting position?

Background: In clinical practice, a manual-based assessment is standard procedure to adjust the air pressure in the ROHO(®) cushion in seated position. Recently, a computerized pressure system method was developed to support the clinical adjustment of air in the ROHO(®) cushion to reduce the pressure in the seated position. To our knowledge, no studies have investigated the reliability between the manual method mostly used in clinical practice and the alternative computer-based assessment of the pressure in the seated position.

Elliptical posts allow for detailed control of non-equibiaxial straining of cell cultures.

Background: A modification of the Flexcell system that allows imposition of homogenous, controlled non-equibiaxial strains to cell cultures is developed and experimentally validated. The Flexcell system by default applies equibiaxial strain to cell cultures, meaning no shear strain, while soft tissue cells in vivo are subjected to a range of mechanical deformations including shear strain caused by activities of daily living. Shear strains are suspected to play an important role in tissue necrosis.

Uniaxial cyclic strain drives assembly and differentiation of skeletal myocytes.

Ex vivo engineering of skeletal muscle represents an exciting new area of biotechnology. Although the ability of skeletal muscle cells to sense and respond to mechanical forces is well known, strategies based on the use of mechanical stimuli to optimize myogenesis in vitro remain limited. In this work, we describe a simple but powerful method based on uniaxial cyclic tensile strain (CTS) to induce assembly and differentiation of skeletal myocytes in vitro.

Missing links in pressure ulcer research--an interdisciplinary overview.

This paper surveys the literature on the etiology of sitting-acquired deep tissue pressure ulcers from three different viewpoints. The first viewpoint is identification of risk factors related to seated posture. The second viewpoint focuses on the external factors that can cause necrosis to human cells, such as ischemia and compression.