Modulation of the intramedullary pressure responses by calcium dobesilate in a rabbit knee model of osteoarthritis.

Background And Purpose: The presence of bone marrow edema in patients with osteoarthritis is associated with pain and disease progression. Management of bone edema with the synthetic prostacyclin iloprost may be complicated by side effects. Calcium dobesilate, a treatment for chronic venous disease, shares some pharmacological actions with iloprost but appears to be better tolerated.