Publications by authors named "Christian D Mireles Davalos"
Article Synopsis
- Thirty-nine clinical isolates from 11 cystic fibrosis patients were analyzed over a 10-year period using whole genome sequencing (WGS) to study their genomic and phenotypic characteristics.
- A single, persistent strain was identified in a long-term patient, showing reduced elastase activity and growth rate, which suggests adaptive changes over time, with no instances of transmission between patients or centers.
- The study highlights unique genomic traits of the isolates, such as the conservation of biofilm and phenazine-related genes, and emphasizes the importance of integrating both genomic and virulence-related phenotypic testing in cystic fibrosis research.
Evaluation of the BD Phoenix Carbapenemase-Producing Organism Panels for the Detection of Carbapenemase Producers in and .
Diagnostics (Basel)
November 2023
The classification of carbapenemases can help guide therapy. The present study evaluated the performance of the CPO detection test, included in the BD Phoenix NMIC-501 panel for the detection and classification of carbapenemases on the representative molecularly characterized strains collection from Mexico. Carbapenem non-susceptible isolates collected in Mexico were included.
View Article and Find Full Text PDFActive Surveillance of Antimicrobial Resistance and Carbapenemase-Encoding Genes According to Sites of Care and Age Groups in Mexico: Results from the INVIFAR Network.
Pathogens
September 2023
We analyzed the antimicrobial resistance (AMR) data of 6519 clinical isolates of ( = 3985), ( = 775), ( = 163), ( = 781), ( = 124), and ( = 691) from 43 centers in Mexico. AMR assays were performed using commercial microdilution systems (37/43) and the disk diffusion susceptibility method (6/43). The presence of carbapenemase-encoding genes was assessed using PCR.
View Article and Find Full Text PDFBackground: Ventilator-Associated pneumonia (VAP) is one of the leading causes of morbidity and mortality in critically ill COVID-19 patients in lower-and-middle-income settings, where timely access to emergency care and accurate diagnostic testing is not widely available. Therefore, rapid microbiological diagnosis is essential to improve effective therapy delivery to affected individuals, preventing adverse outcomes and reducing antimicrobial resistance.
Methods: We conducted a cross-sectional study of patients with suspected VAP and COVID-19, evaluating the diagnostic performance of the BioFire® FilmArray® Pneumonia Panel (FA-PP).
In this study, we report the carbapenemase-encoding genes and colistin resistance in , , , and in the second year of the COVID-19 pandemic. Clinical isolates included carbapenem-resistant , carbapenem-resistant , carbapenem-resistant , and carbapenem-resistant . Carbapenemase-encoding genes were detected by PCR.
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