Melatonin secretion across puberty: A systematic review and meta-analysis.

Background: Melatonin levels decrease with aging and substantially during puberty. Studies have presented distinct melatonin levels in patients with disorders related to their pubertal development compared to healthy controls. The discrepancy suggests that a decrease in melatonin concentrations seen during adolescence might be related to the physical, hormonal, and/or neuronal alterations that occur during the pubertal period.

[Prolonged epistaxis symptom of nasopharynx carcinoma in a child].

This case report presents a ten-year-old boy with recurrent nosebleeds (epistaxis) over an extended period. In addition, he showed signs of slowed weight gain and developed symptoms such as snoring and sweating during sleep. Rhinoscopy revealed a mass in the nasopharynx, and further tests confirmed the presence of an Epstein-Barr Virus-positive nasopharyngeal carcinoma.