Impact of F-FDG PET/MRI on Therapeutic Management of Women with Newly Diagnosed Breast Cancer: Results from a Prospective Double-Center Trial.

Our rationale was to investigate whether F-FDG PET/MRI in addition to (guideline-recommended) conventional staging leads to changes in therapeutic management in patients with newly diagnosed breast cancer and compare the diagnostic accuracy of F-FDG PET/MRI with that of conventional staging for determining the Union for International Cancer Control (UICC) stage. In this prospective, double-center study, 208 women with newly diagnosed, therapy-naïve invasive breast cancer were enrolled in accordance with the inclusion criteria. All patients underwent guideline-recommended conventional staging and whole-body F-FDG PET/MRI with a dedicated breast examination.

Effects of Anti-Tumor Necrosis Factor Therapy on Osteoblastic Activity at Sites of Inflammatory and Structural Lesions in Radiographic Axial Spondyloarthritis: A Prospective Proof-of-Concept Study Using Positron Emission Tomography/Magnetic Resonance Imaging of the Sacroiliac Joints and Spine.

Objective: Proof-of-concept trial to determine the effects of tumor necrosis factor inhibitor (TNFi) therapy on osteoblastic activity at sites of inflammatory and structural lesions in patients with radiographic axial spondyloarthritis (SpA), using fluorine 18-labeled NaF ( F-NaF) positron emission tomography/magnetic resonance imaging (PET/MRI).

Methods: Sixteen patients with clinically active radiographic axial SpA were prospectively enrolled to receive TNFi treatment and undergo F-NaF PET/MRI of the sacroiliac (SI) joints and spine at baseline and at a follow-up visit 3-6 months after treatment initiation. Three readers (1 for PET/MRI and 2 for conventional MRI) evaluated all images, blinded to time point.

Free-breathing 3D Stack of Stars GRE (StarVIBE) sequence for detecting pulmonary nodules in F-FDG PET/MRI.

Background: The free-breathing T1-weighted 3D Stack of Stars GRE (StarVIBE) MR sequence potentially reduces artifacts in chest MRI. The purpose of this study was to evaluate StarVIBE for the detection of pulmonary nodules in F-FDG PET/MRI.

Material And Methods: In this retrospective analysis, conducted on a prospective clinical trial cohort, 88 consecutive women with newly diagnosed breast cancer underwent both contrast-enhanced whole-body F-FDG PET/MRI and computed tomography (CT).

Prospective comparison of CT and 18F-FDG PET/MRI in N and M staging of primary breast cancer patients: Initial results.

Objectives: To compare the diagnostic accuracy of contrast-enhanced thoraco-abdominal computed tomography and whole-body 18F-FDG PET/MRI in N and M staging in newly diagnosed, histopathological proven breast cancer.

Material And Methods: A total of 80 consecutive women with newly diagnosed and histopathologically confirmed breast cancer were enrolled in this prospective study. Following inclusion criteria had to be fulfilled: (1) newly diagnosed, treatment-naive T2-tumor or higher T-stage or (2) newly diagnosed, treatment-naive triple-negative tumor of every size or (3) newly diagnosed, treatment-naive tumor with molecular high risk (T1c, Ki67 >14%, HER2neu over-expression, G3).

Prospective comparison of the diagnostic accuracy of 18F-FDG PET/MRI, MRI, CT, and bone scintigraphy for the detection of bone metastases in the initial staging of primary breast cancer patients.

Objectives: To compare the diagnostic performance of [F]FDG PET/MRI, MRI, CT, and bone scintigraphy for the detection of bone metastases in the initial staging of primary breast cancer patients.

Material And Methods: A cohort of 154 therapy-naive patients with newly diagnosed, histopathologically proven breast cancer was enrolled in this study prospectively. All patients underwent a whole-body [F]FDG PET/MRI, computed tomography (CT) scan, and a bone scintigraphy prior to therapy.

Prospective Correlation of Prognostic Immunohistochemical Markers With SUV and ADC Derived From Dedicated Hybrid Breast 18F-FDG PET/MRI in Women With Newly Diagnosed Breast Cancer.

Purpose: The aim of this study was to correlate prognostically relevant immunohistochemical parameters of breast cancer with simultaneously acquired SUVs and apparent diffusion coefficient (ADC) values derived from hybrid breast PET/MRI.

Patients And Methods: Fifty-six women with newly diagnosed, therapy-naive, histologically proven breast cancer (mean age, 54.1 ± 12.

Impact of F-FDG PET/MR on therapeutic management in high risk primary breast cancer patients - A prospective evaluation of staging algorithms.

Purpose: To investigate whether potential differences in staging between a traditional staging imaging algorithm and F-FDG PET/MR lead to a change in patient management in breast carcinoma and to compare the diagnostic accuracy between the traditional staging algorithm and F-FDG PET/MR for the TNM classification.

Method: In this prospective cohort study from two university hospitals 56 women with newly diagnosed, therapy-naive breast cancer and increased pre-test probability for distant metastases were included. All patients were examined by a traditional staging imaging algorithm (X-ray mammography, breast ultrasonography, chest plain radiography, bone scintigraphy, and ultrasonography of the liver and axillary fossa) and whole-body F-FDG PET/MR including dedicated F-FDG PET/MR breast examinations.

Prospective evaluation of whole-body MRI and F-FDG PET/MRI in N and M staging of primary breast cancer patients.

Objectives: To evaluate and compare the diagnostic potential of whole-body MRI and whole-body F-FDG PET/MRI for N and M staging in newly diagnosed, histopathologically proven breast cancer.

Material And Methods: A total of 104 patients (age 53.4 ± 12.

Incidental F-FDG uptake in the colon: value of contrast-enhanced CT correlation with colonoscopic findings.

Objectives: To evaluate the impact of morphological information derived from contrast-enhanced CT in the characterization of incidental focal colonic uptake in F-FDG PET/CT examinations.

Methods: A total of 125 patients (female: n = 53, male: n = 72) that underwent colonoscopy secondary to contrast-enhanced, full-dose PET/CT without special bowel preparation were included in this retrospective study. PET/CT examinations were assessed for focal colonic tracer uptake in comparison with the background.

Impact of different metal artifact reduction techniques on attenuation correction in 18F-FDG PET/CT examinations.

Objective: To evaluate the impact of different metal artifact reduction (MAR) algorithms on Hounsfield unit (HU) and standardized uptake values (SUV) in a phantom setting and verify these results in patients with metallic implants undergoing oncological PET/CT examinations.

Methods And Materials: In this prospective study, PET-CT examinations of 28 oncological patients (14 female, 14 male, mean age 69.5 ± 15.

Prospective comparison of whole-body MRI and Ga-PSMA PET/CT for the detection of biochemical recurrence of prostate cancer after radical prostatectomy.

Purpose: To assess whole-body magnetic resonance imaging (wb-MRI) for detection of biochemical recurrence in comparison to Ga-prostate-specific membrane antigen positron emission tomography/computed tomography (Ga-PSMA PET/CT) in prostate cancer (Pca) patients after radical prostatectomy.

Methods: This was a prospective trial including 28 consecutive patients (mean age 65.3 ± 9.

Prospective comparison of F-FDG PET/MRI and F-FDG PET/CT for thoracic staging of non-small cell lung cancer.

Objectives: To compare the diagnostic performance of F-FDG PET/MRI and F-FDG PET/CT for primary and locoregional lymph node staging in non-small cell lung cancer (NSCLC).

Methods: In this prospective study, a total of 84 patients (51 men, 33 women, mean age 62.5 ± 9.

Local and whole-body staging in patients with primary breast cancer: a comparison of one-step to two-step staging utilizing F-FDG-PET/MRI.

Objectives: The purpose of this study was to compare the diagnostic value of a one-step to a two-step staging algorithm utilizing F-FDG PET/MRI in breast cancer patients.

Methods: A total of 38 patients (37 females and one male, mean age 57 ± 10 years; range 31-78 years) with newly diagnosed, histopathologically proven breast cancer were prospectively enrolled in this trial. All PET/MRI examinations were assessed for local tumor burden and metastatic spread in two separate reading sessions: (1) One-step algorithm comprising supine whole-body F-FDG PET/MRI, and (2) Two-step algorithm comprising a dedicated prone F-FDG breast PET/MRI and supine whole-body F-FDG PET/MRI.

Heparin-bonded stent graft treatment for major visceral arterial injury after upper abdominal surgery.

Purpose: To analyse technical success, complications, and short- and intermediate-term outcomes after heparin-bonded stent graft implantation for the treatment of major abdominal vessel injury after upper abdominal surgery.

Methods: This retrospective, IRB-approved analysis included 29 consecutive patients (female: n = 6, male: n = 23, mean age 65.9 ± 11.

Dual-phase hybrid F-Fluoride Positron emission tomography/MRI in ankylosing spondylitis: Investigating the link between MRI bone changes, regional hyperaemia and increased osteoblastic activity.

Introduction: Focal F-Fluoride uptake on blood-pool phase PET represents regional hyperaemia, while it indicates osteoblastic activity on mineralization phase PET. This study investigates the link between regional hyperaemia and osteoblastic activity in inflammatory and chronic lesions of ankylosing spondylitis (AS) of the sacroiliac joints (SIJ) using dual-phase F-Fluoride PET/MRI.

Methods: Thirteen patients (six men, seven women, age: 37 ± 10 years) with active AS prospectively underwent dual-phase F-Fluoride PET/MRI.

Imaging children suffering from lymphoma: an evaluation of different F-FDG PET/MRI protocols compared to whole-body DW-MRI.

Objectives: The objectives of this study were to evaluate and compare the diagnostic potential of different PET/MRI reading protocols, entailing non-enhanced / contrast-enhanced and diffusion-weighted F-FDG PET/MR imaging and whole-body diffusion-weighted MRI for lesion detection and determination of the tumor stage in pediatric lymphoma patients.

Methods: A total of 28 F-FDG PET/MRI datasets were included for analysis of four different reading protocols: (1) PET/MRI utilizing sole unenhanced T2w and T1w imaging, (2) PET/MRI utilizing additional contrast enhanced sequences, (3) PET/MR imaging utilizing unenhanced, contrast enhanced and DW imaging or (4) WB-DW-MRI. Statistical analyses were performed on a per-patient and a per-lesion basis.

Evaluation of Practical Interpretation Hurdles in 68Ga-PSMA PET/CT in 55 Patients: Physiological Tracer Distribution and Incidental Tracer Uptake.

Purpose: To investigate the physiologic Ga-PSMA distribution and evaluate focal or diffuse radiotracer uptake in nonprostate cancer malignancies and in incidental findings.

Methods: Ga-PSMA PET/CT scans in 55 men performed for prostate cancer (49) or renal cell carcinoma (6) staging were analyzed retrospectively. Two radiologists evaluated the datasets in 2 reading sessions.

Silent progression in patients with rheumatoid arthritis: is DAS28 remission an insufficient goal in RA? Results from the German Remission-plus cohort.

Background: Remission is arguably the ultimate therapeutic goal in rheumatoid arthritis (RA). Applying modern strategies, clinical remission can be achieved in a substantial number of patients with early RA (ERA). Even in those patients, the number and scope of erosions can increase.

Is integrated 18F-FDG PET/MRI superior to 18F-FDG PET/CT in the differentiation of incidental tracer uptake in the head and neck area?

Purpose: We aimed to investigate the accuracy of 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging (18F-FDG PET/MRI) compared with contrast-enhanced 18F-FDG PET/computed tomography (PET/CT) for the characterization of incidental tracer uptake in examinations of the head and neck.

Methods: A retrospective analysis of 81 oncologic patients who underwent contrast-enhanced 18F-FDG PET/CT and subsequent PET/MRI was performed by two readers for incidental tracer uptake. In a consensus reading, discrepancies were resolved.

Value of F-FDG PET/MRI for the outcome of CT-guided facet block therapy in cervical facet syndrome: initial results.

Introduction: The aim of this study was to evaluate the ability of F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging ( F-FDG PET/MRI) to detect PET-positive cervical facet arthropathy and identify patients who benefit from facet block therapy.

Methods: Ten patients with cervical facet syndrome (mean age: 65 ± 12 years) underwent F-FDG PET/MRI of the neck. Focal F-FDG uptake in PET-positive facet joints served as target for computed tomography (CT)-guided facet blocks.

Malignant pleural mesothelioma: initial experience in integrated (18)F-FDG PET/MR imaging.

Purpose: This study aims to compare staging results of (18)F-FDG PET/computed tomography (CT) and integrated PET/magnetic resonance (MR) in malignant pleural mesothelioma (MPM) patients and to investigate a potential apparent diffusion coefficient (ADC)/SUV correlation.

Materials And Methods: Six patients with MPM underwent (18)F-FDG PET/CT and PET/MR including diffusion-weighted imaging. Thoracic TNM staging was performed for both modalities.

Thoracic staging with F-FDG PET/MR in non-small cell lung cancer - does it change therapeutic decisions in comparison to F-FDG PET/CT?

Objective: To investigate whether differences in thoracic tumour staging between F-FDG PET/CT and PET/MR imaging lead to different therapeutic decisions in Non-Small Cell Lung Cancer (NSCLC).

Material And Methods: Seventy-seven NSCLC patients that underwent whole-body F-FDG PET/CT from the base of skull to the upper thighs and thoracic PET/MR were enrolled in this retrospective study. Thoracic PET/CT and PET/MR images were staged according to the 7th edition of the AJCC staging manual.

Diagnostic potential of PET/CT using a Ga-labelled prostate-specific membrane antigen ligand in whole-body staging of renal cell carcinoma: initial experience.

Purpose: To evaluate the diagnostic potential of whole-body PET/CT using a Ga-labelled PSMA ligand in renal cell carcinoma (RCC).

Methods: Six patients with histopathologically proven RCC underwent Ga-PSMA PET/CT. Each PET/CT scan was evaluated in relation to lesion count, location and dignity.