Publications by authors named "Christian Brice"
Article Synopsis
- - The PREVACT study investigated the effectiveness of immediate reversal of anticoagulation in patients on vitamin K antagonists (VKAs) who suffered mild traumatic brain injury (TBI) to see if it could lower the incidence of intracranial hemorrhage (ICH) within 24 hours of treatment.
- - In a clinical trial across 21 French emergency departments, 202 patients were randomized to either receive immediate reversal treatment or standard care, but the trial was halted early, making it difficult to draw definitive conclusions.
- - Although the results indicated a lower rate of ICH in the intervention group compared to the control group (6.1% vs. 12.1%), the difference was not statistically significant, leaving open
Background: Prophylactic anticoagulation in emergency department patients with lower limb trauma requiring immobilisation is controversial. The Thrombosis Risk Prediction for Patients with Cast Immobilisation-TRiP(cast)-score could identify a large subgroup of patients at low risk of venous thromboembolism for whom prophylactic anticoagulation can be safely withheld. We aimed to prospectively assess the safety of withholding anticoagulation for patients with lower limb trauma at low risk of venous thromboembolism, defined by a TRiP(cast) score of less than 7.
View Article and Find Full Text PDFBackground: The HOME-CoV (Hospitalisation or Outpatient ManagEment of patients with SARS-CoV-2 infection) score is a validated list of uniquely clinical criteria indicating which patients with probable or proven COVID-19 can be treated at home. The aim of this study was to optimise the score to improve its ability to discriminate between patients who do and do not need admission.
Methods: A revised HOME-CoV score was derived using data from a previous prospective multicentre study which evaluated the original Home-CoV score.
Background: The ability of the pulmonary embolism rule-out criteria (PERC) to exclude pulmonary embolism without further testing remains debated outside the USA, especially in the population with suspected pulmonary embolism who have a high prevalence of the condition. Our main objective was to prospectively assess the predictive value of negative PERC to rule out pulmonary embolism among European patients with low implicit clinical probability.
Methods: We did a multicentre, prospective, observational study in 12 emergency departments in France and Belgium.