Sex-specific effect of P2Y purinergic receptor on glucose metabolism during acute inflammation.

The sex of an animal impacts glucose sensitivity, but little information is available regarding the mechanisms causing that difference, especially during acute inflammation. We examined sex-specific differences in the role of the P2Y receptor (P2YR) in glucose flux with and without LPS challenge. Male and female wild-type and P2YR knockout mice (P2YR) were injected with LPS or saline and glucose tolerance tests (GTT) were performed.