Publications by authors named "Christian A M Jongen"
Background/objectives: Extracting spatial features (texture analysis) from dose distributions (dosiomics) for outcome prediction is a rapidly evolving field in radiotherapy. To account for fraction size differences, the biological effective dose (BED) is often calculated. We evaluated the impact and added value of the BED in the dosiomics prediction modelling of grade ≥ 2 late rectal bleeding (LRB) probability within 5 years after treatment in three parts.
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- The study aimed to create a predictive model for late rectal bleeding in prostate cancer patients undergoing different types of radiotherapy.
- Candidate predictors were identified from prior research and five logistic regression models were tested based on various dose parameters.
- Results indicated that certain dosimetric predictors and history of abdominal surgery were significant for predicting the outcome, with some models showing satisfactory internal validation, but external validation is necessary for confirmation.