Membrane-Active Antibiotics Affect Domains in Bacterial Membranes as the First Step of Their Activity.

The need to combat antimicrobial resistance is becoming more and more pressing. Here we investigate the working mechanism of a small cationic agent, -alkylamide 3d, by conventional and high-speed atomic force microscopy. We show that -alkylamide 3d interacts with the membrane of , where it changes the organization and dynamics of lipid domains.