Publications by authors named "Christelle Roger"
Background: The underlying mechanisms of obesity in X-linked hypophosphatemia (XLH) are not known. We aimed to evaluate whether FGF21, an endocrine FGF involved in the regulation of carbohydrate-lipid metabolism, could be involved.
Methods: We performed a prospective multicenter cross-sectional study comparing FGF23, Klotho, and FGF21 levels in teenagers with XLH compared to healthy controls (VITADOS cohort) after matching for age, gender, and puberty.
[Eosinophiluria: accreditation with establishment of an inter-laboratories exchange].
Ann Biol Clin (Paris)
October 2021
Eosinophiluria corresponds to search eosinophils in urine. These are normally absent in urine, their presence could be associated with different clinical conditions affecting kidney or urinary tract. This analysis of medical biology laboratory listed in the French Nomenclature of acts of medical biology has to be validated according to norm NF EN ISO 15189.
View Article and Find Full Text PDFAim: Assessment of mineral metabolism is complex in paediatrics.
Methods: We assessed the evolution of the main mineral and bone biomarkers (total/bone alkaline phosphatase ALP/BAP, β-crosslaps, osteocalcin, sclerostin, C-terminal and intact FGF23) in 100 healthy teenagers (10-18 years, 50 boys).
Results: At a mean age of 13.
The quantification of urine albumin is a common practice in Medical Biology laboratories. It allows the assessment of renal injury in common pathologies and many studies have confirmed its role in the diagnosis and prognosis of these disorders. The physicochemical characteristics of albumin in the urine, very different from those in the blood, do not allow the use of the same standardized assay techniques for the blood albumin determination and make it difficult its quantification.
View Article and Find Full Text PDFObjectives: Differentiated thyroid cancer (DTC) requires long-term follow-up by serum thyroglobulin assay and cervical ultrasound, due to the risk of recurrence. Guidelines recommend basal assay under hormone therapy at 3 months, repeated at 6-12 months post-surgery, with or without associated isotopic ablation, after stimulation by recombinant human TSH to improve assay sensitivity. It was hypothesized that a new-generation assay kit with lower limits of detection and quantification would improve the sensitivity of the basal assay, enhance detection of premature recurrence and decrease the rate of false-negatives, thereby avoiding the need for the complementary stimulation test.
View Article and Find Full Text PDF[Focus on preanalytics for Down's syndrome screening during first trimester of pregnancy].
Ann Biol Clin (Paris)
January 2015
Article Synopsis
- The study explores the best pre-analytical conditions for screening Down's syndrome using maternal serum markers in the first trimester.
- It finds that serum samples can be stored at 2–8°C for up to 72 hours with a 5% acceptable bias in marker concentration, and withstand three freeze-thaw cycles without affecting results.
- The research aims to create guidelines for handling and transporting blood samples, emphasizing the importance of maintaining sample integrity to avoid potentially serious clinical consequences.
Article Synopsis
- The study aimed to compare two tests, ELISA and a bead-based multiplex flow immunoassay (MFA), for detecting anti-CCP autoantibodies in a cohort of 705 patients, including those with rheumatic symptoms and systemic lupus erythematosus (SLE).
- Results showed a high level of agreement between the two methods, with similar sensitivity and specificity for diagnosing rheumatoid arthritis (RA), indicating both tests are effective.
- The conclusion suggests that the MFA is a reliable option for routine testing of anti-CCP autoantibodies and could potentially replace ELISA, reserving it for secondary testing in certain situations.