Publications by authors named "Christelle Aunac"
Biochim Biophys Acta
March 2004
Article Synopsis
- Researchers used a phage-displayed peptide library to identify an epitope recognized by five monoclonal antibodies targeting recombinant human lamin A.
- The antibodies were shown to bind to both lamin A and C, with a critical nine-amino acid sequence (PLLTYRFPP) identified as the binding site, structured as a beta-strand in the Ig-like domain.
- The sequence contains arginine-482 (R482), which is mutated in Dunnigan-type familial partial lipodystrophy, suggesting its potential role in interactions with proteins linked to this condition.
