Publications by authors named "Christel E Smeele"
Rationale: Compulsivity often develops during childhood and is associated with elevated glutamate levels within the frontostriatal system. This suggests that anti-glutamatergic drugs, like memantine, may be an effective treatment.
Objective: Our goal was to characterize the acute and chronic effect of memantine treatment on compulsive behavior and frontostriatal network structure and function in an adolescent rat model of compulsivity.
Article Synopsis
- OCD is now seen as a condition that develops in the brain, especially in kids and teenagers.
- Researchers used young rats to study how compulsive behaviors, like checking things repeatedly, change as they grow.
- The study found that the rats showed this compulsive checking after certain injections, revealing changes in their brain structure that could help us understand OCD better and find new treatments.